DegronMD - Q8N4N8(KIF2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A33V	TCGA-27-1836	GBM	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	TCGA-AA-A010	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	TCGA-CA-6717	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	TCGA-XK-AAJP	PRAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	DO8264	COAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	DO230347	COCA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	DO13138	GBM	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	DO225420	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A33V	DO51410	PRAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.T57K	TCGA-34-7107	LUSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.T57K	DO26449	LUSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.W55C	TCGA-51-6867	LUSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1111
p.W55C	DO26477	LUSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1111
p.R36H	TCGA-A6-2681	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	TCGA-AG-4021	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	TCGA-AX-A1CA	UCEC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	DO9788	COAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	DO33184	PACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	DO34192	PACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	DO36605	READ	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	DO42873	UCEC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	SIDM00643	Non-Cancerous	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36H	ACH-002363	Non-Cancerous	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.T47M	TCGA-AB-2838	LAML	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6312
p.T47M	DO21319	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6312
p.R40W	TCGA-AG-3898	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8634
p.R40W	DO37356	READ	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8634
p.R40W	SIDM01770	Gastric Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8634
p.R40W	ACH-000908	Gastric Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.8634
p.T57M	TCGA-AG-A00C	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.T57M	TCGA-EA-A410	CESC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.T57M	DO49929	CESC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.0556
p.R36S	TCGA-CV-6945	HNSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36S	DO15767	HNSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	TCGA-HT-A5RA	LGG	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	DO224846	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	DO44589	LGG	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	DO23358	LINC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	DO45297	LIRI	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36C	DO36221	PRAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R40Q	TCGA-IN-A6RL	STAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.R40Q	DO233207	GACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.R40Q	DO51738	STAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.7329
p.N50K	TCGA-MN-A4N5	LUAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.N50K	DO45332	LUAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.I49N	DO222794	COCA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.2778
p.A33T	DO233823	GACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1667
p.A44P	DO231625	LINC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6392
p.V32M	DO221128	MALY	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.H42Y	DO220877	MELA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.6118
p.K39N	SIDM00721	Small Cell Lung Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5806
p.K39N	ACH-002171	Lung Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5806
p.K39N	NCI-H250	lung	COSMIC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation altering degron motif	0.5806
p.V32A	SIDM01608	Endometrial Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.1389
p.R36L	SIDM01665	Colorectal Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25
p.R36L	ACH-000089	Colon/Colorectal Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	39:47	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIF2B

UniProt ID: Q8N4N8

Entrez ID: 84643

Protein name: Kinesin-like protein KIF2B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIF2B in