DegronMD

Uniprot ID: Q8N4N8

Source protein: Kinesin-like protein KIF2B

Source gene: KIF2B

Class: DEG_APCC_DBOX_1

Location: 39:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5821

ASA_SCORE: 48

COIL: 0.2098

CONS_SCORE: 0.5011

DSS_SCORE: 0.0952

HELIX: 0.0013

FCONS_SCORE: 1.2844

RIG_SCORE: 0.9094

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A33V	TCGA-27-1836	GBM	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	TCGA-AA-A010	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	TCGA-CA-6717	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	TCGA-XK-AAJP	PRAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	DO8264	COAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	DO230347	COCA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	DO13138	GBM	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	DO225420	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A33V	DO51410	PRAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.T57K	TCGA-34-7107	LUSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.0556
p.T57K	DO26449	LUSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.0556
p.W55C	TCGA-51-6867	LUSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.1111
p.W55C	DO26477	LUSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1111
p.R36H	TCGA-A6-2681	COAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	TCGA-AG-4021	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	TCGA-AX-A1CA	UCEC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	DO9788	COAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	DO33184	PACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	DO34192	PACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	DO36605	READ	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	DO42873	UCEC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	SIDM00643	Non-Cancerous	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36H	ACH-002363	Non-Cancerous	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.T47M	TCGA-AB-2838	LAML	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.6312
p.T47M	DO21319	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.6312
p.R40W	TCGA-AG-3898	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.8634
p.R40W	DO37356	READ	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.8634
p.R40W	SIDM01770	Gastric Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	0.8634
p.R40W	ACH-000908	Gastric Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	0.8634
p.T57M	TCGA-AG-A00C	READ	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.0556
p.T57M	TCGA-EA-A410	CESC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.0556
p.T57M	DO49929	CESC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.0556
p.R36S	TCGA-CV-6945	HNSC	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36S	DO15767	HNSC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	TCGA-HT-A5RA	LGG	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	DO224846	LAML	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	DO44589	LGG	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	DO23358	LINC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	DO45297	LIRI	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36C	DO36221	PRAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R40Q	TCGA-IN-A6RL	STAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.7329
p.R40Q	DO233207	GACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.7329
p.R40Q	DO51738	STAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.7329
p.N50K	TCGA-MN-A4N5	LUAD	TCGA	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.N50K	DO45332	LUAD	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.I49N	DO222794	COCA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.2778
p.A33T	DO233823	GACA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1667
p.A44P	DO231625	LINC	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.6392
p.V32M	DO221128	MALY	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1389
p.H42Y	DO220877	MELA	ICGC	KRIHLAVVT	DEG_APCC_DBOX_1	0.6118
p.K39N	SIDM00721	Small Cell Lung Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	0.5806
p.K39N	ACH-002171	Lung Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	0.5806
p.K39N	NCI-H250	lung	COSMIC	KRIHLAVVT	DEG_APCC_DBOX_1	0.5806
p.V32A	SIDM01608	Endometrial Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	0.1389
p.R36L	SIDM01665	Colorectal Carcinoma	GDSC	KRIHLAVVT	DEG_APCC_DBOX_1	0.25
p.R36L	ACH-000089	Colon/Colorectal Cancer	CCLE	KRIHLAVVT	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRIHLAVVT

Degron related mutations and impact score

Drug responses associated with KIF2B mutations

All proteins holding degron of KRIHLAVVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4N8	Kinesin-like protein KIF2B	DEG_APCC_DBOX_1	39:47	KRIHLAVVT	APC,CDC20,FZR1	0.5821	More...