DegronMD - Q8N4T4(ARHGEF39)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P263T	TCGA-24-2033	OV	TCGA	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0556
p.P263T	DO32143	OV	ICGC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0556
p.P238T	TCGA-39-5031	LUSC	TCGA	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0556
p.P238T	DO26526	LUSC	ICGC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0556
p.P260T	TCGA-EJ-5524	PRAD	TCGA	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.1389
p.P260T	DO36284	PRAD	ICGC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.1389
p.R246H	DO230346	COCA	ICGC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2778
p.D253G	DO229240	THCA	ICGC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation altering degron motif	0.7198
p.R244Q	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2222
p.R244Q	ACH-000056	Lymphoma	CCLE	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2222
p.R244Q	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2222
p.P262L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0833
p.P262L	ACH-000309	Lung Cancer	CCLE	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0833
p.P262L	SK-LU-1	lung	COSMIC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.0833
p.R246C	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2778
p.R246C	ACH-001642	Lymphoma	CCLE	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2778
p.R246C	SCC-3	haematopoietic and lymphoid tissue	COSMIC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2778
p.M257T	SIDM00808	Burkitt's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2222
p.M257T	SIDM01254	Burkitt's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	248:253	Mutation rewiring degron network	0.2222

Kaplan plot for ARHGEF39 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF39

UniProt ID: Q8N4T4

Entrez ID: 84904

Protein name: Rho guanine nucleotide exchange factor 39

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF39 in