DegronMD

Uniprot ID: Q8N4T4

Source protein: Rho guanine nucleotide exchange factor 39

Source gene: ARHGEF39

Class: LIG_APCC_ABBA_1

Location: 248:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6917

ASA_SCORE: 13.5667

COIL: 0.3522

CONS_SCORE: 0.8858

DSS_SCORE: 0.0928

HELIX: 0.0105

FCONS_SCORE: 1.352

RIG_SCORE: 0.9601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P263T	TCGA-24-2033	OV	TCGA	FFLFTD	LIG_APCC_ABBA_1	0.0556
p.P263T	DO32143	OV	ICGC	FFLFTD	LIG_APCC_ABBA_1	0.0556
p.P238T	TCGA-39-5031	LUSC	TCGA	FFLFTD	LIG_APCC_ABBA_1	0.0556
p.P238T	DO26526	LUSC	ICGC	FFLFTD	LIG_APCC_ABBA_1	0.0556
p.P260T	TCGA-EJ-5524	PRAD	TCGA	FFLFTD	LIG_APCC_ABBA_1	0.1389
p.P260T	DO36284	PRAD	ICGC	FFLFTD	LIG_APCC_ABBA_1	0.1389
p.R246H	DO230346	COCA	ICGC	FFLFTD	LIG_APCC_ABBA_1	0.2778
p.D253G	DO229240	THCA	ICGC	FFLFTD	LIG_APCC_ABBA_1	0.7198
p.R244Q	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	0.2222
p.R244Q	ACH-000056	Lymphoma	CCLE	FFLFTD	LIG_APCC_ABBA_1	0.2222
p.R244Q	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	FFLFTD	LIG_APCC_ABBA_1	0.2222
p.P262L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	0.0833
p.P262L	ACH-000309	Lung Cancer	CCLE	FFLFTD	LIG_APCC_ABBA_1	0.0833
p.P262L	SK-LU-1	lung	COSMIC	FFLFTD	LIG_APCC_ABBA_1	0.0833
p.R246C	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	0.2778
p.R246C	ACH-001642	Lymphoma	CCLE	FFLFTD	LIG_APCC_ABBA_1	0.2778
p.R246C	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	FFLFTD	LIG_APCC_ABBA_1	0.2778
p.M257T	SIDM00808	Burkitt's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	0.2222
p.M257T	SIDM01254	Burkitt's Lymphoma	GDSC	FFLFTD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N4T4	Rho guanine nucleotide exchange factor 39	LIG_APCC_ABBA_1	248:253	FFLFTD	APC,CDC20,FZR1	0.6917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons