DegronMD - Q8N554(ZNF276)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D380Y	TCGA-50-5932	LUAD	TCGA	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.S398R	TCGA-55-7283	LUAD	TCGA	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.E340K	TCGA-AC-A23H	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.E340K	DO2401	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.S378Y	TCGA-AP-A1DV	UCEC	TCGA	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation blocking phosphorylation signal	0.6389
p.D354H	TCGA-BP-5202	KIRC	TCGA	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.S382F	TCGA-E7-A7XN	BLCA	TCGA	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation blocking phosphorylation signal	0.75
p.G393C	TCGA-FS-A1ZP	SKCM	TCGA	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1944
p.P384L	DO51907	BLCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.7582
p.A356T	DO219084	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.A356T	DO223699	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.A356S	DO219078	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1111
p.R373W	DO737	BLCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.1667
p.R373W	DO8490	COAD	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.1667
p.T350M	DO9956	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2778
p.E391D	DO229016	COCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.E391D	DO229480	LAML	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.E391D	DO229505	LAML	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.E391D	DO228941	LICA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.E391D	DO231141	LUSC	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.R348Q	DO52110	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7329
p.D343H	DO18046	KIRC	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.3056
p.C342S	DO22592	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2778
p.R392C	DO22237	LGG	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.G379V	DO229029	LICA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation blocking phosphorylation signal	0.6667
p.G348V	DO229036	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7532
p.L390V	DO23130	LINC	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.V394L	DO219129	LUSC	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.2778
p.V388A	DO222843	MELA	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.6936
p.A351V	DO232838	NACA	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.25
p.R392H	DO52151	PAEN	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.P386S	DO36353	PRAD	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.6752
p.V352M	DO51346	PRAD	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.2222
p.P376H	DO37442	SKCM	ICGC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1389
p.P345H	DO47491	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7694
p.R348W	DO41644	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.8634
p.R347Q	DO43755	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation altering degron motif	0.7329
p.L338F	SIDM00216	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.L338F	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.L338F	SNU-175	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.1667
p.K394N	SIDM01106	Melanoma	GDSC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.2778
p.K394N	ACH-000822	Skin Cancer	CCLE	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.2778
p.K394N	SK-MEL-24	skin	COSMIC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.2778
p.R335Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation rewiring degron network	0.0833
p.Y353H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	344:348	Mutation substituting flanking lysine	0.3056
p.D387N	YAPC	pancreas	COSMIC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.6932
p.K382R	SNU-C2B	large intestine	COSMIC	FEPYPE	LIG_APCC_ABBA_1	383:388	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF276

UniProt ID: Q8N554

Entrez ID: 92822

Protein name: Zinc finger protein 276 (Zfp-276) (Zinc finger protein 477)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF276 in