DegronMD

Uniprot ID: Q8N554

Source protein: Zinc finger protein 276

Source gene: ZNF276

Class: LIG_APCC_ABBA_1

Location: 383:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9837

ASA_SCORE: 100.4833

COIL: 0.76

CONS_SCORE: 0.9621

DSS_SCORE: 0.7004

HELIX: 0.08

FCONS_SCORE: 1.0855

RIG_SCORE: 0.6314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D380Y	TCGA-50-5932	LUAD	TCGA	FEPYPE	LIG_APCC_ABBA_1	0.25
p.S398R	TCGA-55-7283	LUAD	TCGA	FEPYPE	LIG_APCC_ABBA_1	0.0556
p.S378Y	TCGA-AP-A1DV	UCEC	TCGA	FEPYPE	LIG_APCC_ABBA_1	0.6389
p.S382F	TCGA-E7-A7XN	BLCA	TCGA	FEPYPE	LIG_APCC_ABBA_1	0.75
p.G393C	TCGA-FS-A1ZP	SKCM	TCGA	FEPYPE	LIG_APCC_ABBA_1	0.1944
p.P384L	DO51907	BLCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.7582
p.R373W	DO737	BLCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.1667
p.R373W	DO8490	COAD	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.1667
p.E391D	DO229016	COCA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.25
p.E391D	DO229480	LAML	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.25
p.E391D	DO229505	LAML	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.25
p.E391D	DO228941	LICA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.25
p.E391D	DO231141	LUSC	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.25
p.R392C	DO22237	LGG	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.2222
p.G379V	DO229029	LICA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.6667
p.L390V	DO23130	LINC	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.2778
p.V394L	DO219129	LUSC	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.2778
p.V388A	DO222843	MELA	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.6936
p.R392H	DO52151	PAEN	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.2222
p.P386S	DO36353	PRAD	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.6752
p.P376H	DO37442	SKCM	ICGC	FEPYPE	LIG_APCC_ABBA_1	0.1389
p.K394N	SIDM01106	Melanoma	GDSC	FEPYPE	LIG_APCC_ABBA_1	0.2778
p.K394N	ACH-000822	Skin Cancer	CCLE	FEPYPE	LIG_APCC_ABBA_1	0.2778
p.K394N	SK-MEL-24	skin	COSMIC	FEPYPE	LIG_APCC_ABBA_1	0.2778
p.D387N	YAPC	pancreas	COSMIC	FEPYPE	LIG_APCC_ABBA_1	0.6932
p.K382R	SNU-C2B	large_intestine	COSMIC	FEPYPE	LIG_APCC_ABBA_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N554	Zinc finger protein 276	LIG_APCC_ABBA_1	383:388	FEPYPE	APC,CDC20,FZR1	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons