DegronMD - Q8N5C7(DTWD1)

DTWD1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D191N	TCGA-DK-A6B6	BLCA	TCGA	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0833
p.D191N	DO48576	BLCA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0833
p.D206N	DO234334	ESAD	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.6932
p.Y194C	DO233238	GACA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.1667
p.K205E	DO219857	LGG	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation altering degron motif	0.7022
p.S192R	DO229031	LICA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation blocking phosphorylation signal	0.5556
p.L190I	DO43041	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0556
p.L190I	DO41572	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.0556
p.S195Y	DO41584	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation substituting flanking lysine	0.3056
p.S195Y	DO42793	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation substituting flanking lysine	0.3056
p.G196D	SIDM01056	Breast Carcinoma	GDSC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.2222
p.G196D	ACH-000330	Breast Cancer	CCLE	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.2222
p.G196D	EFM-19	breast	COSMIC	KKIIFID	LIG_APCC_ABBAyCdc20_2	200:206	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc