DegronMD

Uniprot ID: Q8N5C7

Source protein: tRNA-uridine aminocarboxypropyltransferase 1

Source gene: DTWD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 200:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6854

ASA_SCORE: 28.0857

COIL: 0.1707

CONS_SCORE: 0.636

DSS_SCORE: 0.1536

HELIX: 0.0296

FCONS_SCORE: 1.4861

RIG_SCORE: 0.9347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D191N	TCGA-DK-A6B6	BLCA	TCGA	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.0833
p.D191N	DO48576	BLCA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.0833
p.D206N	DO234334	ESAD	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.6932
p.Y194C	DO233238	GACA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.1667
p.K205E	DO219857	LGG	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.7022
p.S192R	DO229031	LICA	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.5556
p.L190I	DO43041	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.L190I	DO41572	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.0556
p.S195Y	DO41584	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.3056
p.S195Y	DO42793	UCEC	ICGC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.3056
p.G196D	SIDM01056	Breast Carcinoma	GDSC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G196D	ACH-000330	Breast Cancer	CCLE	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.2222
p.G196D	EFM-19	breast	COSMIC	KKIIFID	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5C7	tRNA-uridine aminocarboxypropyltransferase 1	LIG_APCC_ABBAyCdc20_2	200:206	KKIIFID	APC,CDC20,FZR1	0.6854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons