DegronMD - Q8N5D0(WDTC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R363H	TCGA-BR-8591	STAD	TCGA	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.8244
p.R363H	DO47973	STAD	ICGC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.8244
p.R363C	TCGA-QG-A5Z2	COAD	TCGA	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.8301
p.R363C	DO44096	COAD	ICGC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation altering degron motif	0.8301
p.A371S	DO228976	LICA	ICGC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.1111
p.E357K	SIDM00183	Small Cell Lung Carcinoma	GDSC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.3056
p.E357K	LB647-SCLC	lung	COSMIC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.3056
p.E356K	ACH-002154	Lung Cancer	CCLE	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2778
p.E356K	LB647-SCLC	lung	COSMIC	LPPYLE	LIG_APCC_ABBA_1	358:363	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons