DegronMD

Uniprot ID: Q8N5D0

Source protein: WD and tetratricopeptide repeats protein 1

Source gene: WDTC1

Class: LIG_APCC_ABBA_1

Location: 358:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9551

ASA_SCORE: 55.0333

COIL: 0.3358

CONS_SCORE: 0.5235

DSS_SCORE: 0.4366

HELIX: 0.6452

FCONS_SCORE: 1.1979

RIG_SCORE: 0.7957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R363H	TCGA-BR-8591	STAD	TCGA	LPPYLE	LIG_APCC_ABBA_1	0.8244
p.R363H	DO47973	STAD	ICGC	LPPYLE	LIG_APCC_ABBA_1	0.8244
p.R363C	TCGA-QG-A5Z2	COAD	TCGA	LPPYLE	LIG_APCC_ABBA_1	0.8301
p.R363C	DO44096	COAD	ICGC	LPPYLE	LIG_APCC_ABBA_1	0.8301
p.A371S	DO228976	LICA	ICGC	LPPYLE	LIG_APCC_ABBA_1	0.1111
p.E357K	SIDM00183	Small Cell Lung Carcinoma	GDSC	LPPYLE	LIG_APCC_ABBA_1	0.3056
p.E357K	LB647-SCLC	lung	COSMIC	LPPYLE	LIG_APCC_ABBA_1	0.3056
p.E356K	ACH-002154	Lung Cancer	CCLE	LPPYLE	LIG_APCC_ABBA_1	0.2778
p.E356K	LB647-SCLC	lung	COSMIC	LPPYLE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5D0	WD and tetratricopeptide repeats protein 1	LIG_APCC_ABBA_1	358:363	LPPYLE	APC,CDC20,FZR1	0.9551	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons