DegronMD - Q8N5J4(SPIC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R35I	TCGA-19-5956	GBM	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.8102
p.R35I	DO13863	GBM	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.8102
p.V47F	TCGA-43-A474	LUSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1944
p.V47F	DO45490	LUSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1944
p.G49V	TCGA-66-2759	LUSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.G49V	DO27326	LUSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.S51F	TCGA-BS-A0UV	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.S51F	TCGA-D6-6516	HNSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.S51F	DO15623	HNSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.S51F	DO42793	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0833
p.L28I	TCGA-D1-A103	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.L28I	DO42312	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1667
p.P45T	TCGA-DF-A2KU	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.P45T	DO223286	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.25
p.S52I	DO228976	LICA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.0556
p.Q29P	DO220866	MELA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1944
p.G49E	DO220875	MELA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation rewiring degron network	0.1389
p.N42D	DO232761	PBCA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	34:42	Mutation altering degron motif	0.5821

Kaplan plot for SPIC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPIC

UniProt ID: Q8N5J4

Entrez ID: 121599

Protein name: Transcription factor Spi-C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPIC in