DegronMD

Uniprot ID: Q8N5J4

Source protein: Transcription factor Spi-C

Source gene: SPIC

Class: DEG_APCC_DBOX_1

Location: 34:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8117

ASA_SCORE: 78.5778

COIL: 0.657

CONS_SCORE: 0.6275

DSS_SCORE: 0.2826

HELIX: 0.2758

FCONS_SCORE: 1.1528

RIG_SCORE: 0.8113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R35I	TCGA-19-5956	GBM	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.8102
p.R35I	DO13863	GBM	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.8102
p.V47F	TCGA-43-A474	LUSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.1944
p.V47F	DO45490	LUSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.1944
p.G49V	TCGA-66-2759	LUSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.1389
p.G49V	DO27326	LUSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.1389
p.S51F	TCGA-BS-A0UV	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.0833
p.S51F	TCGA-D6-6516	HNSC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.0833
p.S51F	DO15623	HNSC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.0833
p.S51F	DO42793	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.0833
p.L28I	TCGA-D1-A103	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.1667
p.L28I	DO42312	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.1667
p.P45T	TCGA-DF-A2KU	UCEC	TCGA	YRNYLALIN	DEG_APCC_DBOX_1	0.25
p.P45T	DO223286	UCEC	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.25
p.S52I	DO228976	LICA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.0556
p.Q29P	DO220866	MELA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.1944
p.G49E	DO220875	MELA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.1389
p.N42D	DO232761	PBCA	ICGC	YRNYLALIN	DEG_APCC_DBOX_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5J4	Transcription factor Spi-C	DEG_APCC_DBOX_1	34:42	YRNYLALIN	APC,CDC20,FZR1	0.8117	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons