DegronMD - Q8N6N2(TTC9B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S60C	TCGA-UB-A7MB	LIHC	TCGA	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.S60C	DO52318	LIHC	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.T47A	DO8360	COAD	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.825
p.S60I	DO229259	THCA	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.S41L	SIDM01307	Colorectal Carcinoma	GDSC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation rewiring degron network	0.25
p.S60G	SIDM00118	Colorectal Carcinoma	GDSC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.S60G	ACH-001081	Colon/Colorectal Cancer	CCLE	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.S60G	HCC2998	large intestine	COSMIC	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation blocking phosphorylation signal	0.5278
p.G45R	ACH-000861	Lung Cancer	CCLE	PGPTPEPS	DEG_SCF_FBW7_1	44:51	Mutation altering degron motif	0.6457

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons