DegronMD

Uniprot ID: Q8N6N2

Source protein: Tetratricopeptide repeat protein 9B

Source gene: TTC9B

Class: DEG_SCF_FBW7_1

Location: 44:51

E3 ligase: FBXW7

DEGRON score: 0.9775

ASA_SCORE: 82.25

COIL: 0.9529

CONS_SCORE: 0.2215

DSS_SCORE: 0.7665

HELIX: 0.0285

FCONS_SCORE: 0.9555

RIG_SCORE: 0.5056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S60C	TCGA-UB-A7MB	LIHC	TCGA	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.S60C	DO52318	LIHC	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.T47A	DO8360	COAD	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	0.825
p.S60I	DO229259	THCA	ICGC	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.S41L	SIDM01307	Colorectal Carcinoma	GDSC	PGPTPEPS	DEG_SCF_FBW7_1	0.25
p.S60G	SIDM00118	Colorectal Carcinoma	GDSC	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.S60G	ACH-001081	Colon/Colorectal Cancer	CCLE	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.S60G	HCC2998	large_intestine	COSMIC	PGPTPEPS	DEG_SCF_FBW7_1	0.5278
p.G45R	ACH-000861	Lung Cancer	CCLE	PGPTPEPS	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6N2	Tetratricopeptide repeat protein 9B	DEG_SCF_FBW7_1	44:51	PGPTPEPS	FBXW7	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons