DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
TEX9
UniProt ID:
Q8N6V9
Entrez ID:
374618
Protein name:
Testis-expressed protein 9
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
TEX9
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TCGA
ICGC
COSMIC
CCLE
GDSC
Show Degron:
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.P92A
TCGA-34-5239
LUSC
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1944
p.P92A
DO27660
LUSC
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1944
p.H100N
TCGA-66-2788
LUSC
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation altering degron motif
0.7423
p.H100N
DO26749
LUSC
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation altering degron motif
0.7423
p.R88I
TCGA-EE-A181
SKCM
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.0833
p.R88I
DO37444
SKCM
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.0833
p.N109H
TCGA-EO-A22X
UCEC
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1389
p.N109H
DO43907
UCEC
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1389
p.L99I
TCGA-EW-A6SD
BRCA
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation altering degron motif
0.6063
p.L99I
DO223936
BRCA
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation altering degron motif
0.6063
p.L90V
TCGA-KK-A8I7
PRAD
TCGA
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1389
p.L90V
DO219319
PRAD
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.1389
p.L99P
DO229245
THCA
ICGC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation altering degron motif
0.6471
p.K104M
SIDM01217
Other Blood Cancers
GDSC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.2778
p.K104M
MY-M12
haematopoietic and lymphoid tissue
COSMIC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.2778
p.D103N
H513
pleura
COSMIC
VHLHSE
LIG_APCC_ABBA_1
97:102
Mutation rewiring degron network
0.3056
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for TEX9 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc