DegronMD

Uniprot ID: Q8N6V9

Source protein: Testis-expressed protein 9

Source gene: TEX9

Class: LIG_APCC_ABBA_1

Location: 97:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7975

ASA_SCORE: 89.6833

COIL: 0.7137

CONS_SCORE: 0.5401

DSS_SCORE: 0.5571

HELIX: 0.1092

FCONS_SCORE: 1.2421

RIG_SCORE: 0.7112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P92A	TCGA-34-5239	LUSC	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.1944
p.P92A	DO27660	LUSC	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.1944
p.H100N	TCGA-66-2788	LUSC	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.7423
p.H100N	DO26749	LUSC	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.7423
p.R88I	TCGA-EE-A181	SKCM	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.0833
p.R88I	DO37444	SKCM	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.0833
p.N109H	TCGA-EO-A22X	UCEC	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.1389
p.N109H	DO43907	UCEC	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.1389
p.L99I	TCGA-EW-A6SD	BRCA	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.6063
p.L99I	DO223936	BRCA	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.6063
p.L90V	TCGA-KK-A8I7	PRAD	TCGA	VHLHSE	LIG_APCC_ABBA_1	0.1389
p.L90V	DO219319	PRAD	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.1389
p.L99P	DO229245	THCA	ICGC	VHLHSE	LIG_APCC_ABBA_1	0.6471
p.K104M	SIDM01217	Other Blood Cancers	GDSC	VHLHSE	LIG_APCC_ABBA_1	0.2778
p.K104M	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	VHLHSE	LIG_APCC_ABBA_1	0.2778
p.D103N	H513	pleura	COSMIC	VHLHSE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6V9	Testis-expressed protein 9	LIG_APCC_ABBA_1	97:102	VHLHSE	APC,CDC20,FZR1	0.7975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons