DegronMD - Q8N729(NPW)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P158H	TCGA-CN-6989	HNSC	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6583
p.S144F	TCGA-EE-A20F	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.0833
p.P162T	TCGA-EE-A2A0	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.3056
p.R145L	TCGA-EE-A2MD	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1111
p.R154C	SIDM00422	Hodgkin's Lymphoma	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.8301
p.R154C	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.8301
p.A151T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.A151T	SIDM00333	Endometrial Carcinoma	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.A151T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.A151T	MFE-319	endometrium	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.A161T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6028
p.A161T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.6028
p.P150H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25
p.P164L	Sarc9371	bone	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25
p.P164S	Sarc9371	bone	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.25

Kaplan plot for NPW in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPW

UniProt ID: Q8N729

Entrez ID: 283869

Protein name: Neuropeptide W (Preproprotein L8) (hPPL8) [Cleaved into: Neuropeptide W-23 (NPW23) (hL8); Neuropeptide W-30 (NPW30) (hL8C)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPW in