DegronMD

Uniprot ID: Q8N729

Source protein: Neuropeptide W

Source gene: NPW

Class: DEG_APCC_DBOX_1

Location: 153:161

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9843

ASA_SCORE: 77.8222

COIL: 0.8583

CONS_SCORE: 0.4535

DSS_SCORE: 0.4734

HELIX: 0.0769

FCONS_SCORE: 0.8602

RIG_SCORE: 0.7342

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P158H	TCGA-CN-6989	HNSC	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	0.6583
p.S144F	TCGA-EE-A20F	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	0.0833
p.P162T	TCGA-EE-A2A0	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	0.3056
p.R145L	TCGA-EE-A2MD	SKCM	TCGA	NRLGLPCLA	DEG_APCC_DBOX_1	0.1111
p.R154C	SIDM00422	Hodgkin's Lymphoma	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	0.8301
p.R154C	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.8301
p.A151T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	0.2778
p.A151T	SIDM00333	Endometrial Carcinoma	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	0.2778
p.A151T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.2778
p.A151T	MFE-319	endometrium	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.2778
p.A161T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	0.6028
p.A161T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.6028
p.P150H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	NRLGLPCLA	DEG_APCC_DBOX_1	0.25
p.P164L	Sarc9371	bone	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.25
p.P164S	Sarc9371	bone	COSMIC	NRLGLPCLA	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N729	Neuropeptide W	DEG_APCC_DBOX_1	153:161	NRLGLPCLA	APC,CDC20,FZR1	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons