DegronMD - Q8N7B6(PACRGL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R57T	TCGA-2G-AAGA	TGCT	TCGA	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.0556
p.R75P	TCGA-55-7910	LUAD	TCGA	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.25
p.R75P	DO23669	LUAD	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.25
p.R75Q	TCGA-BR-4362	STAD	TCGA	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.25
p.R75Q	DO38336	STAD	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.25
p.S59I	TCGA-FI-A2D5	UCEC	TCGA	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1111
p.S59I	DO41331	UCEC	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1111
p.S59I	SIDM00669	Pancreatic Carcinoma	GDSC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1111
p.S59I	ACH-000094	Pancreatic Cancer	CCLE	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1111
p.S59I	HPAF-II	pancreas	COSMIC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1111
p.E75K	DO51642	CESC	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.25
p.K65N	DO223536	CLLE	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.2778
p.S72L	DO48538	LGG	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.7667
p.S71R	DO45193	LIRI	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.7427
p.P69L	DO222420	MELA	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.6471
p.V70A	DO232224	PBCA	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.6936
p.V76M	DO51407	PRAD	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.2222
p.H71Y	DO37412	SKCM	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.7229
p.G70R	DO42033	UCEC	ICGC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation altering degron motif	0.7568
p.P58S	SIDM01217	Other Blood Cancers	GDSC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.0833
p.P58S	ACH-002276	Leukemia	CCLE	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.0833
p.P58S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.0833
p.Y78S	ACH-000652	Pancreatic Cancer	CCLE	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1667
p.Y78S	SUIT-2	pancreas	COSMIC	INPFGE	LIG_APCC_ABBA_1	67:72	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PACRGL

UniProt ID: Q8N7B6

Entrez ID: 133015

Protein name: PACRG-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PACRGL in