DegronMD

Uniprot ID: Q8N7B6

Source protein: PACRG-like protein

Source gene: PACRGL

Class: LIG_APCC_ABBA_1

Location: 67:72

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9863

ASA_SCORE: 75.35

COIL: 0.83

CONS_SCORE: 0.7989

DSS_SCORE: 0.5753

HELIX: 0.1185

FCONS_SCORE: 0.9883

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R57T	TCGA-2G-AAGA	TGCT	TCGA	INPFGE	LIG_APCC_ABBA_1	0.0556
p.R75P	TCGA-55-7910	LUAD	TCGA	INPFGE	LIG_APCC_ABBA_1	0.25
p.R75P	DO23669	LUAD	ICGC	INPFGE	LIG_APCC_ABBA_1	0.25
p.R75Q	TCGA-BR-4362	STAD	TCGA	INPFGE	LIG_APCC_ABBA_1	0.25
p.R75Q	DO38336	STAD	ICGC	INPFGE	LIG_APCC_ABBA_1	0.25
p.S59I	TCGA-FI-A2D5	UCEC	TCGA	INPFGE	LIG_APCC_ABBA_1	0.1111
p.S59I	DO41331	UCEC	ICGC	INPFGE	LIG_APCC_ABBA_1	0.1111
p.S59I	SIDM00669	Pancreatic Carcinoma	GDSC	INPFGE	LIG_APCC_ABBA_1	0.1111
p.S59I	ACH-000094	Pancreatic Cancer	CCLE	INPFGE	LIG_APCC_ABBA_1	0.1111
p.S59I	HPAF-II	pancreas	COSMIC	INPFGE	LIG_APCC_ABBA_1	0.1111
p.E75K	DO51642	CESC	ICGC	INPFGE	LIG_APCC_ABBA_1	0.25
p.K65N	DO223536	CLLE	ICGC	INPFGE	LIG_APCC_ABBA_1	0.2778
p.S72L	DO48538	LGG	ICGC	INPFGE	LIG_APCC_ABBA_1	0.7667
p.S71R	DO45193	LIRI	ICGC	INPFGE	LIG_APCC_ABBA_1	0.7427
p.P69L	DO222420	MELA	ICGC	INPFGE	LIG_APCC_ABBA_1	0.6471
p.V70A	DO232224	PBCA	ICGC	INPFGE	LIG_APCC_ABBA_1	0.6936
p.V76M	DO51407	PRAD	ICGC	INPFGE	LIG_APCC_ABBA_1	0.2222
p.H71Y	DO37412	SKCM	ICGC	INPFGE	LIG_APCC_ABBA_1	0.7229
p.G70R	DO42033	UCEC	ICGC	INPFGE	LIG_APCC_ABBA_1	0.7568
p.P58S	SIDM01217	Other Blood Cancers	GDSC	INPFGE	LIG_APCC_ABBA_1	0.0833
p.P58S	ACH-002276	Leukemia	CCLE	INPFGE	LIG_APCC_ABBA_1	0.0833
p.P58S	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	INPFGE	LIG_APCC_ABBA_1	0.0833
p.Y78S	ACH-000652	Pancreatic Cancer	CCLE	INPFGE	LIG_APCC_ABBA_1	0.1667
p.Y78S	SUIT-2	pancreas	COSMIC	INPFGE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7B6	PACRG-like protein	LIG_APCC_ABBA_1	67:72	INPFGE	APC,CDC20,FZR1	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons