DegronMD - Q8N7B9(EFCAB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L196I	TCGA-55-7907	LUAD	TCGA	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation altering degron motif	0.7174
p.L196I	DO25396	LUAD	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation altering degron motif	0.7174
p.S209Y	TCGA-F5-6814	READ	TCGA	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.0833
p.S209Y	DO52505	EOPC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.0833
p.S209Y	DO36556	READ	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.0833
p.I190V	TCGA-KD-A5QU	SARC	TCGA	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.2222
p.I190V	DO223272	SARC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.2222
p.K208N	DO228971	LICA	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.1111
p.S197T	DO45093	LIRI	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation altering degron motif	0.7116
p.L205I	DO230931	LUSC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.1944
p.L205I	DO224548	LUSC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.1944
p.A185S	SIDM00053	Pancreatic Carcinoma	GDSC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.0833
p.A185S	MZ1-PC	pancreas	COSMIC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation rewiring degron network	0.0833
p.T196I	ACH-000917	Esophageal Cancer	CCLE	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation altering degron motif	0.8189
p.T196I	TE-4	oesophagus	COSMIC	ICTPPSS	DEG_SCF_FBW7_1	194:200	Mutation altering degron motif	0.8189

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons