DegronMD

Uniprot ID: Q8N7B9

Source protein: EF-hand calcium-binding domain-containing protein 3

Source gene: EFCAB3

Class: DEG_SCF_FBW7_1

Location: 194:200

E3 ligase: FBXW7

DEGRON score: 0.9257

ASA_SCORE: 80.5

COIL: 0.9173

CONS_SCORE: 0.5309

DSS_SCORE: 0.3379

HELIX: 0.0464

FCONS_SCORE: 0.9003

RIG_SCORE: 0.7522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L196I	TCGA-55-7907	LUAD	TCGA	ICTPPSS	DEG_SCF_FBW7_1	0.7174
p.L196I	DO25396	LUAD	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.7174
p.S209Y	TCGA-F5-6814	READ	TCGA	ICTPPSS	DEG_SCF_FBW7_1	0.0833
p.S209Y	DO52505	EOPC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.0833
p.S209Y	DO36556	READ	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.0833
p.I190V	TCGA-KD-A5QU	SARC	TCGA	ICTPPSS	DEG_SCF_FBW7_1	0.2222
p.I190V	DO223272	SARC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.2222
p.K208N	DO228971	LICA	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.1111
p.S197T	DO45093	LIRI	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.7116
p.L205I	DO230931	LUSC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.1944
p.L205I	DO224548	LUSC	ICGC	ICTPPSS	DEG_SCF_FBW7_1	0.1944
p.A185S	SIDM00053	Pancreatic Carcinoma	GDSC	ICTPPSS	DEG_SCF_FBW7_1	0.0833
p.A185S	MZ1-PC	pancreas	COSMIC	ICTPPSS	DEG_SCF_FBW7_1	0.0833
p.T196I	ACH-000917	Esophageal Cancer	CCLE	ICTPPSS	DEG_SCF_FBW7_1	0.8189
p.T196I	TE-4	oesophagus	COSMIC	ICTPPSS	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7B9	EF-hand calcium-binding domain-containing protein 3	DEG_SCF_FBW7_1	194:200	ICTPPSS	FBXW7	0.9257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons