DegronMD - Q8N7J2(AMER2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P500T	TCGA-2W-A8YY	CESC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.25
p.P500T	DO223732	CESC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.25
p.D484Y	TCGA-78-8662	LUAD	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.D484Y	DO45346	LUAD	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.D484Y	DO231047	LUSC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.R490C	TCGA-AX-A05Z	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8301
p.R490C	DO40884	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8301
p.R490C	SIDM00469	Pancreatic Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8301
p.R490C	PSN1	pancreas	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8301
p.R490H	TCGA-BS-A0UV	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8244
p.R490H	DO42793	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.8244
p.R495Q	TCGA-D1-A17U	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6218
p.R495Q	DO41887	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6218
p.R491M	TCGA-D3-A2J6	SKCM	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.7521
p.R491M	DO37901	SKCM	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.7521
p.I498M	TCGA-DK-A3X1	BLCA	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.3056
p.I498M	DO447	BLCA	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.3056
p.P506H	DO222445	BTCA	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833
p.K483T	DO234237	ESAD	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation substituting flanking lysine	0.2778
p.A485T	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2222
p.A485T	A427	lung	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2222
p.A481V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1111
p.A481V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1111
p.P497H	SIDM01617	Endometrial Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.6583
p.N498S	ACH-002309	Sarcoma	CCLE	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.3056
p.D484G	HSC-2	upper aerodigestive tract	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944

Kaplan plot for AMER2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMER2

UniProt ID: Q8N7J2

Entrez ID: 219287

Protein name: APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMER2 in