DegronMD

Uniprot ID: Q8N7J2

Source protein: APC membrane recruitment protein 2

Source gene: AMER2

Class: DEG_APCC_DBOX_1

Location: 489:497

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9892

ASA_SCORE: 115.3556

COIL: 0.6388

CONS_SCORE: 0.6249

DSS_SCORE: 0.6363

HELIX: 0.3357

FCONS_SCORE: 1.4258

RIG_SCORE: 0.6729

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R490C	TCGA-AX-A05Z	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.8301
p.R490C	DO40884	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.8301
p.R490C	SIDM00469	Pancreatic Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	0.8301
p.R490C	PSN1	pancreas	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	0.8301
p.R490H	TCGA-BS-A0UV	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.8244
p.R490H	DO42793	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.8244
p.R491M	TCGA-D3-A2J6	SKCM	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.7521
p.R491M	DO37901	SKCM	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.7521
p.P497H	SIDM01617	Endometrial Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	0.6583
p.R495Q	TCGA-D1-A17U	UCEC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.6218
p.R495Q	DO41887	UCEC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.6218
p.I498M	TCGA-DK-A3X1	BLCA	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.3056
p.I498M	DO447	BLCA	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.3056
p.N498S	ACH-002309	Sarcoma	CCLE	KRRRLNRIP	DEG_APCC_DBOX_1	0.3056
p.K483T	DO234237	ESAD	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.2778
p.P500T	TCGA-2W-A8YY	CESC	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.25
p.P500T	DO223732	CESC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.25
p.A485T	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	0.2222
p.A485T	A427	lung	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	0.2222
p.D484Y	TCGA-78-8662	LUAD	TCGA	KRRRLNRIP	DEG_APCC_DBOX_1	0.1944
p.D484Y	DO45346	LUAD	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.1944
p.D484Y	DO231047	LUSC	ICGC	KRRRLNRIP	DEG_APCC_DBOX_1	0.1944
p.D484G	HSC-2	upper_aerodigestive_tract	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	0.1944
p.A481V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	KRRRLNRIP	DEG_APCC_DBOX_1	0.1111
p.A481V	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	KRRRLNRIP	DEG_APCC_DBOX_1	0.1111

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Drug responses associated with AMER2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KRRRLNRIP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7J2	APC membrane recruitment protein 2	DEG_APCC_DBOX_1	489:497	KRRRLNRIP	APC,CDC20,FZR1	0.9892	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRRRLNRIP

Degron related mutations and impact score

Drug responses associated with AMER2 mutations

All proteins holding degron of KRRRLNRIP