DegronMD - Q8N7R1(POM121L12)

GO - Biological processes (BP): protein import into nucleus [GO:0006606]; RNA export from nucleus [GO:0006405]

GO - Molecular function (MF): nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]

GO - Cellular component (CC): nuclear pore [GO:0005643]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
PSTPQTT	DEG_SCF_FBW7_1	FBXW7	POM121-like protein 12	37:43	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T43M	TCGA-AA-3966	COAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	TCGA-CR-6488	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	DO10068	COAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	DO14368	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.P40L	TCGA-DA-A95Z	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.P40L	DO219481	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.P40L	ACH-001664	Gastric Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.S36L	ACH-001233	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.75
p.T39M	TCGA-98-8021	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	DO27468	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	DO232072	ORCA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	ACH-000636	Leukemia	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T43S	SIDM01298	Esophageal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7116
p.P40T	TCGA-04-1542	OV	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7031
p.P40T	DO31729	OV	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7031
p.S34R	SIDM00365	Small Cell Lung Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944
p.S34R	ACH-002196	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944
p.S34R	SBC-1	lung	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944

Showing 1 to 20 of 73 entries

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No resistance data available for this Degron.

Kaplan plot for POM121L12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POM121L12

UniProt ID: Q8N7R1

Entrez ID: 285877

Protein name: POM121-like protein 12

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for POM121L12 in