DegronMD - Q8N7R1(POM121L12)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P40T	TCGA-04-1542	OV	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7031
p.P40T	DO31729	OV	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7031
p.P37L	TCGA-39-5016	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6471
p.P37L	TCGA-AA-3968	COAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6471
p.P37L	DO9178	COAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6471
p.P37L	DO26701	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6471
p.P46T	TCGA-44-6774	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.P46T	DO25000	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.Q47K	TCGA-46-3768	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.Q47K	DO26466	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.A31S	TCGA-50-5049	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.A31S	DO23705	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.L29M	TCGA-78-7148	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1111
p.L29M	DO26112	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1111
p.A31T	TCGA-86-A4JF	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.A31T	DO45317	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.A31T	DO220879	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.P32H	TCGA-91-8499	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.P32H	DO228627	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.P32H	DO233179	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.P32H	DO45349	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.T39M	TCGA-98-8021	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	DO27468	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	DO232072	ORCA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	ACH-000636	Leukemia	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T39M	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7423
p.T43M	TCGA-AA-3966	COAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	TCGA-CR-6488	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	DO10068	COAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.T43M	DO14368	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.8534
p.S38R	TCGA-AP-A059	UCEC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6316
p.S38R	DO41361	UCEC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.6316
p.G48D	TCGA-BF-A5EP	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.G48D	DO223906	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1944
p.A30E	TCGA-BR-8680	STAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A30E	TCGA-CR-7365	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A30E	DO15991	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A30E	DO47769	STAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A30T	TCGA-CR-7365	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A30T	DO15991	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.P40L	TCGA-DA-A95Z	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.P40L	DO219481	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.P40L	ACH-001664	Gastric Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7582
p.P46L	TCGA-EE-A2A0	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.P46L	DO37439	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.P46S	TCGA-WE-A8ZX	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.P46S	DO222363	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.P46S	DO51291	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.25
p.D27N	DO233871	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.D27N	SIDM00282	Colorectal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.D27N	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.D27N	CW-2	large intestine	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.Q50R	DO23378	LINC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.A28V	DO229177	LMS	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0833
p.Q47R	DO228371	MALY	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.Q47R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.Q47R	ACH-000315	Lymphoma	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.Q47R	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.2222
p.R49C	DO222653	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1667
p.P52L	DO222875	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0833
p.A30V	DO34688	PACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.1389
p.T43S	SIDM01298	Esophageal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation altering degron motif	0.7116
p.W53C	SIDM00719	Small Cell Lung Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.W53C	ACH-001364	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.W53C	NCI-H345	lung	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0556
p.A28T	SIDM00498	Colorectal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0833
p.A28T	ACH-000970	Colon/Colorectal Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0833
p.A28T	SNU-C5	large intestine	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation rewiring degron network	0.0833
p.S34R	SIDM00365	Small Cell Lung Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944
p.S34R	ACH-002196	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944
p.S34R	SBC-1	lung	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.6944
p.S36L	ACH-001233	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	37:43	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POM121L12

UniProt ID: Q8N7R1

Entrez ID: 285877

Protein name: POM121-like protein 12

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POM121L12 in