DegronMD

Uniprot ID: Q8N7R1

Source protein: POM121-like protein 12

Source gene: POM121L12

Class: DEG_SCF_FBW7_1

Location: 37:43

E3 ligase: FBXW7

DEGRON score: 0.8433

ASA_SCORE: 91.8143

COIL: 0.9619

CONS_SCORE: 0

DSS_SCORE: 0.8337

HELIX: 0.0134

FCONS_SCORE: 0

RIG_SCORE: 0.5372

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40T	TCGA-04-1542	OV	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.7031
p.P40T	DO31729	OV	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.7031
p.P37L	TCGA-39-5016	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.6471
p.P37L	TCGA-AA-3968	COAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.6471
p.P37L	DO9178	COAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.6471
p.P37L	DO26701	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.6471
p.P46T	TCGA-44-6774	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.P46T	DO25000	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.Q47K	TCGA-46-3768	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.Q47K	DO26466	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.A31S	TCGA-50-5049	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.A31S	DO23705	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.L29M	TCGA-78-7148	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1111
p.L29M	DO26112	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1111
p.A31T	TCGA-86-A4JF	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.A31T	DO45317	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.A31T	DO220879	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.P32H	TCGA-91-8499	LUAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.P32H	DO228627	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.P32H	DO233179	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.P32H	DO45349	LUAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.T39M	TCGA-98-8021	LUSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T39M	DO27468	LUSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T39M	DO232072	ORCA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T39M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T39M	ACH-000636	Leukemia	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T39M	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.7423
p.T43M	TCGA-AA-3966	COAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.8534
p.T43M	TCGA-CR-6488	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.8534
p.T43M	DO10068	COAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.8534
p.T43M	DO14368	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.8534
p.S38R	TCGA-AP-A059	UCEC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.6316
p.S38R	DO41361	UCEC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.6316
p.G48D	TCGA-BF-A5EP	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.G48D	DO223906	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1944
p.A30E	TCGA-BR-8680	STAD	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A30E	TCGA-CR-7365	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A30E	DO15991	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A30E	DO47769	STAD	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A30T	TCGA-CR-7365	HNSC	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A30T	DO15991	HNSC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.P40L	TCGA-DA-A95Z	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.7582
p.P40L	DO219481	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.7582
p.P40L	ACH-001664	Gastric Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.7582
p.P46L	TCGA-EE-A2A0	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.P46L	DO37439	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.P46S	TCGA-WE-A8ZX	SKCM	TCGA	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.P46S	DO222363	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.P46S	DO51291	SKCM	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.25
p.D27N	DO233871	GACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.D27N	SIDM00282	Colorectal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.D27N	ACH-000998	Colon/Colorectal Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.D27N	CW-2	large_intestine	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.Q50R	DO23378	LINC	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.A28V	DO229177	LMS	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.0833
p.Q47R	DO228371	MALY	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.Q47R	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.Q47R	ACH-000315	Lymphoma	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.Q47R	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.2222
p.R49C	DO222653	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1667
p.P52L	DO222875	MELA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.0833
p.A30V	DO34688	PACA	ICGC	PSTPQTT	DEG_SCF_FBW7_1	0.1389
p.T43S	SIDM01298	Esophageal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.7116
p.W53C	SIDM00719	Small Cell Lung Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.W53C	ACH-001364	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.W53C	NCI-H345	lung	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.0556
p.A28T	SIDM00498	Colorectal Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.0833
p.A28T	ACH-000970	Colon/Colorectal Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.0833
p.A28T	SNU-C5	large_intestine	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.0833
p.S34R	SIDM00365	Small Cell Lung Carcinoma	GDSC	PSTPQTT	DEG_SCF_FBW7_1	0.6944
p.S34R	ACH-002196	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.6944
p.S34R	SBC-1	lung	COSMIC	PSTPQTT	DEG_SCF_FBW7_1	0.6944
p.S36L	ACH-001233	Lung Cancer	CCLE	PSTPQTT	DEG_SCF_FBW7_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPQTT

Degron related mutations and impact score

Drug responses associated with POM121L12 mutations

All proteins holding degron of PSTPQTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N7R1	POM121-like protein 12	DEG_SCF_FBW7_1	37:43	PSTPQTT	FBXW7	0.8433	More...