DegronMD - Q8N8E3(CEP112)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M231I	TCGA-44-6144	LUAD	TCGA	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6507
p.M231I	DO24190	LUAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.6507
p.S241G	TCGA-A8-A094	BRCA	TCGA	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1944
p.S241G	DO2593	BRCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1944
p.K234E	TCGA-B5-A11N	UCEC	TCGA	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.591
p.K234E	DO41458	UCEC	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.591
p.K224N	TCGA-IB-7651	PAAD	TCGA	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation substituting flanking lysine	0.2778
p.K224N	DO46657	PAAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation substituting flanking lysine	0.2778
p.L238V	DO230321	COCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2778
p.R222H	DO227996	COCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.Q244R	DO50810	LICA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.S240F	DO220862	MELA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.2222
p.R222C	DO218900	SKCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.1111
p.A237T	DO51777	STAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.3056
p.D246Y	SIDM00193	Colorectal Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.D246Y	SIDM00214	Colorectal Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.D246Y	ACH-000955	Colon/Colorectal Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.D246Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.D246Y	SNU-407	large intestine	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.D246Y	SNU-81	large intestine	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556
p.T232S	SIDM01664	Prostate Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.7116
p.T232S	ACH-000952	Prostate Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation altering degron motif	0.7116
p.E246D	MEG-01	haematopoietic and lymphoid tissue	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	230:236	Mutation rewiring degron network	0.0556

Kaplan plot for CEP112 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP112

UniProt ID: Q8N8E3

Entrez ID: 201134

Protein name: Centrosomal protein of 112 kDa (Cep112) (Coiled-coil domain-containing protein 46)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP112 in