DegronMD

Uniprot ID: Q8N8E3

Source protein: Centrosomal protein of 112 kDa

Source gene: CEP112

Class: DEG_SCF_FBW7_1

Location: 230:236

E3 ligase: FBXW7

DEGRON score: 0.9953

ASA_SCORE: 100.6286

COIL: 0.8186

CONS_SCORE: 0.7963

DSS_SCORE: 0.3714

HELIX: 0.1501

FCONS_SCORE: 0.9711

RIG_SCORE: 0.748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M231I	TCGA-44-6144	LUAD	TCGA	LMTPKFS	DEG_SCF_FBW7_1	0.6507
p.M231I	DO24190	LUAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.6507
p.S241G	TCGA-A8-A094	BRCA	TCGA	LMTPKFS	DEG_SCF_FBW7_1	0.1944
p.S241G	DO2593	BRCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.1944
p.K234E	TCGA-B5-A11N	UCEC	TCGA	LMTPKFS	DEG_SCF_FBW7_1	0.591
p.K234E	DO41458	UCEC	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.591
p.K224N	TCGA-IB-7651	PAAD	TCGA	LMTPKFS	DEG_SCF_FBW7_1	0.2778
p.K224N	DO46657	PAAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.2778
p.L238V	DO230321	COCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.2778
p.R222H	DO227996	COCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.1111
p.Q244R	DO50810	LICA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.1111
p.S240F	DO220862	MELA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.2222
p.R222C	DO218900	SKCA	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.1111
p.A237T	DO51777	STAD	ICGC	LMTPKFS	DEG_SCF_FBW7_1	0.3056
p.D246Y	SIDM00193	Colorectal Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.D246Y	SIDM00214	Colorectal Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.D246Y	ACH-000955	Colon/Colorectal Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.D246Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.D246Y	SNU-407	large_intestine	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.D246Y	SNU-81	large_intestine	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	0.0556
p.T232S	SIDM01664	Prostate Carcinoma	GDSC	LMTPKFS	DEG_SCF_FBW7_1	0.7116
p.T232S	ACH-000952	Prostate Cancer	CCLE	LMTPKFS	DEG_SCF_FBW7_1	0.7116
p.E246D	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	LMTPKFS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8E3	Centrosomal protein of 112 kDa	DEG_SCF_FBW7_1	230:236	LMTPKFS	FBXW7	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons