DegronMD - Q8N8F6(YIPF7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S95P	TCGA-17-Z017	LUAD	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.3056
p.A94T	TCGA-A5-A0GP	UCEC	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A94T	TCGA-AG-3891	READ	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A94T	DO36388	READ	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A94T	DO41109	UCEC	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A94T	SIDM00660	Colorectal Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A94T	LS-411N	large intestine	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.2778
p.A87T	TCGA-BA-A6DD	HNSC	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87T	DO233168	GACA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87T	DO44452	HNSC	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87T	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87T	NCI-H1944	lung	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.G88E	TCGA-CG-5721	STAD	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1111
p.G88E	DO38192	STAD	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1111
p.P104L	TCGA-DD-A3A8	LIHC	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation altering degron motif	0.7582
p.P104L	DO44883	LIHC	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation altering degron motif	0.7582
p.P114S	TCGA-FW-A3R5	SKCM	TCGA	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0556
p.P114S	DO37406	SKCM	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0556
p.S95C	DO223022	ESCA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.3056
p.P113L	DO233111	GACA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.Q89H	DO233618	GACA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1389
p.Y100F	DO228947	LICA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation altering degron motif	0.7528
p.F109Y	DO222494	MELA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1944
p.E112K	DO228014	SKCA	ICGC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1111
p.P113T	SIDM01040	Ovarian Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	SIDM01005	Acute Myeloid Leukemia	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	SIDM00619	Thyroid Gland Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	SIDM01695	Acute Myeloid Leukemia	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	SIDM00167	Head and Neck Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	FU-OV-1	ovary	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.P113T	KMH-2	thyroid	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87V	SIDM00217	Colorectal Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.A87V	SNU-1040	large intestine	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.0833
p.Q104H	ACH-000945	Lung Cancer	CCLE	NSDYYSQSP	CBL_PTK	96:104	Mutation altering degron motif	0.7582
p.Q104H	NCI-H650	lung	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation altering degron motif	0.7582
p.P89T	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1389
p.P89T	FU-OV-1	ovary	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1389
p.P89T	KMH-2	thyroid	COSMIC	NSDYYSQSP	CBL_PTK	96:104	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YIPF7

UniProt ID: Q8N8F6

Entrez ID: 285525

Protein name: Protein YIPF7 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9) (YIP1 family member 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YIPF7 in