DegronMD

Uniprot ID: Q8N8F6

Source protein: Protein YIPF7

Source gene: YIPF7

Class: CBL_PTK

Location: 96:104

E3 ligase: CBL

DEGRON score: 0.9859

ASA_SCORE: 71.9333

COIL: 0.8329

CONS_SCORE: 0.4308

DSS_SCORE: 0.4005

HELIX: 0.1109

FCONS_SCORE: 0.7938

RIG_SCORE: 0.705

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S95P	TCGA-17-Z017	LUAD	TCGA	NSDYYSQSP	CBL_PTK	0.3056
p.A94T	TCGA-A5-A0GP	UCEC	TCGA	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	TCGA-AG-3891	READ	TCGA	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	DO36388	READ	ICGC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	DO41109	UCEC	ICGC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	SIDM00660	Colorectal Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	LS-411N	large_intestine	COSMIC	NSDYYSQSP	CBL_PTK	0.2778
p.A87T	TCGA-BA-A6DD	HNSC	TCGA	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	DO233168	GACA	ICGC	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	DO44452	HNSC	ICGC	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	NCI-H1944	lung	COSMIC	NSDYYSQSP	CBL_PTK	0.0833
p.G88E	TCGA-CG-5721	STAD	TCGA	NSDYYSQSP	CBL_PTK	0.1111
p.G88E	DO38192	STAD	ICGC	NSDYYSQSP	CBL_PTK	0.1111
p.P104L	TCGA-DD-A3A8	LIHC	TCGA	NSDYYSQSP	CBL_PTK	0.7582
p.P104L	DO44883	LIHC	ICGC	NSDYYSQSP	CBL_PTK	0.7582
p.P114S	TCGA-FW-A3R5	SKCM	TCGA	NSDYYSQSP	CBL_PTK	0.0556
p.P114S	DO37406	SKCM	ICGC	NSDYYSQSP	CBL_PTK	0.0556
p.S95C	DO223022	ESCA	ICGC	NSDYYSQSP	CBL_PTK	0.3056
p.P113L	DO233111	GACA	ICGC	NSDYYSQSP	CBL_PTK	0.0833
p.Q89H	DO233618	GACA	ICGC	NSDYYSQSP	CBL_PTK	0.1389
p.Y100F	DO228947	LICA	ICGC	NSDYYSQSP	CBL_PTK	0.7528
p.F109Y	DO222494	MELA	ICGC	NSDYYSQSP	CBL_PTK	0.1944
p.E112K	DO228014	SKCA	ICGC	NSDYYSQSP	CBL_PTK	0.1111
p.P113T	SIDM01040	Ovarian Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	SIDM01005	Acute Myeloid Leukemia	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	SIDM00619	Thyroid Gland Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	SIDM01695	Acute Myeloid Leukemia	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	SIDM00167	Head and Neck Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	FU-OV-1	ovary	COSMIC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	NSDYYSQSP	CBL_PTK	0.0833
p.P113T	KMH-2	thyroid	COSMIC	NSDYYSQSP	CBL_PTK	0.0833
p.A87V	SIDM00217	Colorectal Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833
p.A87V	SNU-1040	large_intestine	COSMIC	NSDYYSQSP	CBL_PTK	0.0833
p.Q104H	ACH-000945	Lung Cancer	CCLE	NSDYYSQSP	CBL_PTK	0.7582
p.Q104H	NCI-H650	lung	COSMIC	NSDYYSQSP	CBL_PTK	0.7582
p.P89T	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	NSDYYSQSP	CBL_PTK	0.1389
p.P89T	FU-OV-1	ovary	COSMIC	NSDYYSQSP	CBL_PTK	0.1389
p.P89T	KMH-2	thyroid	COSMIC	NSDYYSQSP	CBL_PTK	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NSDYYSQSP

Degron related mutations and impact score

Drug responses associated with YIPF7 mutations

All proteins holding degron of NSDYYSQSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8F6	Protein YIPF7	CBL_PTK	96:104	NSDYYSQSP	CBL	0.9859	More...