DegronMD

Uniprot ID: Q8N8F6

Source protein: Protein YIPF7

Source gene: YIPF7

Class: CBL_PTK

Location: 96:104

E3 ligase: CBL

DEGRON score: 0.9859

ASA_SCORE: 71.9333

COIL: 0.8329

CONS_SCORE: 0.4308

DSS_SCORE: 0.4005

HELIX: 0.1109

FCONS_SCORE: 0.7938

RIG_SCORE: 0.705

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P104L	TCGA-DD-A3A8	LIHC	TCGA	NSDYYSQSP	CBL_PTK	0.7582
p.P104L	DO44883	LIHC	ICGC	NSDYYSQSP	CBL_PTK	0.7582
p.Q104H	ACH-000945	Lung Cancer	CCLE	NSDYYSQSP	CBL_PTK	0.7582
p.Q104H	NCI-H650	lung	COSMIC	NSDYYSQSP	CBL_PTK	0.7582
p.Y100F	DO228947	LICA	ICGC	NSDYYSQSP	CBL_PTK	0.7528
p.S95P	TCGA-17-Z017	LUAD	TCGA	NSDYYSQSP	CBL_PTK	0.3056
p.S95C	DO223022	ESCA	ICGC	NSDYYSQSP	CBL_PTK	0.3056
p.A94T	TCGA-A5-A0GP	UCEC	TCGA	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	TCGA-AG-3891	READ	TCGA	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	DO36388	READ	ICGC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	DO41109	UCEC	ICGC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	SIDM00660	Colorectal Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.2778
p.A94T	LS-411N	large_intestine	COSMIC	NSDYYSQSP	CBL_PTK	0.2778
p.F109Y	DO222494	MELA	ICGC	NSDYYSQSP	CBL_PTK	0.1944
p.Q89H	DO233618	GACA	ICGC	NSDYYSQSP	CBL_PTK	0.1389
p.P89T	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	NSDYYSQSP	CBL_PTK	0.1389
p.P89T	FU-OV-1	ovary	COSMIC	NSDYYSQSP	CBL_PTK	0.1389
p.P89T	KMH-2	thyroid	COSMIC	NSDYYSQSP	CBL_PTK	0.1389
p.G88E	TCGA-CG-5721	STAD	TCGA	NSDYYSQSP	CBL_PTK	0.1111
p.G88E	DO38192	STAD	ICGC	NSDYYSQSP	CBL_PTK	0.1111
p.E112K	DO228014	SKCA	ICGC	NSDYYSQSP	CBL_PTK	0.1111
p.A87T	TCGA-BA-A6DD	HNSC	TCGA	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	DO233168	GACA	ICGC	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	DO44452	HNSC	ICGC	NSDYYSQSP	CBL_PTK	0.0833
p.A87T	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	NSDYYSQSP	CBL_PTK	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N8F6	Protein YIPF7	CBL_PTK	96:104	NSDYYSQSP	CBL	0.9859	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons