DegronMD - Q8N954(GPATCH11)

GPATCH11

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E53D	TCGA-B5-A11G	UCEC	TCGA	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6758
p.E53D	DO43514	UCEC	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6758
p.P47A	DO225448	GACA	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6392
p.E52D	DO20899	KIRP	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6758
p.M53L	DO20899	KIRP	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.711
p.R60L	DO229027	LICA	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1389
p.K37N	DO228525	PRAD	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1111
p.N48H	DO41133	UCEC	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.7423
p.I45T	SIDM01175	Other Sarcomas	GDSC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5966
p.I45T	SIDM00982	Glioblastoma	GDSC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5966
p.I45T	42-MG-BA	central nervous system	COSMIC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5966
p.I45T	SW684	soft tissue	COSMIC	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.5966
p.D60H	ACH-000379	Lung Cancer	CCLE	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation rewiring degron network	0.1389
p.P50A	ACH-001690	Head and Neck Cancer	CCLE	IRPGLPMLR	DEG_APCC_DBOX_1	45:53	Mutation altering degron motif	0.6392

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc