DegronMD

Uniprot ID: Q8N954

Source protein: G patch domain-containing protein 11

Source gene: GPATCH11

Class: DEG_APCC_DBOX_1

Location: 45:53

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7843

ASA_SCORE: 92.1889

COIL: 0.8299

CONS_SCORE: 0.4674

DSS_SCORE: 0.4464

HELIX: 0.1518

FCONS_SCORE: 0.9386

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E53D	TCGA-B5-A11G	UCEC	TCGA	IRPGLPMLR	DEG_APCC_DBOX_1	0.6758
p.E53D	DO43514	UCEC	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.6758
p.P47A	DO225448	GACA	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.6392
p.E52D	DO20899	KIRP	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.6758
p.M53L	DO20899	KIRP	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.711
p.R60L	DO229027	LICA	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.1389
p.K37N	DO228525	PRAD	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.1111
p.N48H	DO41133	UCEC	ICGC	IRPGLPMLR	DEG_APCC_DBOX_1	0.7423
p.I45T	SIDM01175	Other Sarcomas	GDSC	IRPGLPMLR	DEG_APCC_DBOX_1	0.5966
p.I45T	SIDM00982	Glioblastoma	GDSC	IRPGLPMLR	DEG_APCC_DBOX_1	0.5966
p.I45T	42-MG-BA	central_nervous_system	COSMIC	IRPGLPMLR	DEG_APCC_DBOX_1	0.5966
p.I45T	SW684	soft_tissue	COSMIC	IRPGLPMLR	DEG_APCC_DBOX_1	0.5966
p.D60H	ACH-000379	Lung Cancer	CCLE	IRPGLPMLR	DEG_APCC_DBOX_1	0.1389
p.P50A	ACH-001690	Head and Neck Cancer	CCLE	IRPGLPMLR	DEG_APCC_DBOX_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N954	G patch domain-containing protein 11	DEG_APCC_DBOX_1	45:53	IRPGLPMLR	APC,CDC20,FZR1	0.7843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons