DegronMD - Q8N957(ANKFN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D166N	TCGA-43-8118	LUSC	TCGA	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.3056
p.D166N	DO45471	LUSC	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.3056
p.G174V	TCGA-50-5941	LUAD	TCGA	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.3056
p.G174V	DO25528	LUAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.3056
p.P162Q	TCGA-BF-A1PU	SKCM	TCGA	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1944
p.P162Q	DO50278	SKCM	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1944
p.P162R	TCGA-DK-A3IK	BLCA	TCGA	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1944
p.P162R	DO454	BLCA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1944
p.L165P	DO50345	ESAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.2778
p.L165P	DO223116	ESCA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.2778
p.Q159R	DO234345	ESAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1111
p.M183I	DO231016	LUSC	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.0556
p.E173K	DO222546	MELA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation altering degron motif	0.7022
p.S172N	SIDM00150	Colorectal Carcinoma	GDSC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation altering degron motif	0.5958
p.S172N	ACH-000969	Colon/Colorectal Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation altering degron motif	0.5958
p.S172N	KM12	large intestine	COSMIC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation altering degron motif	0.5958
p.T176A	SIDM01491	Colorectal Carcinoma	GDSC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.25
p.T176A	ACH-000342	Colon/Colorectal Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.25
p.D179G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1667
p.D179G	ACH-000942	Leukemia	CCLE	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.1667
p.P177S	ACH-001518	Endometrial/Uterine Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.2222
p.D166H	EPLC-272H	lung	COSMIC	LNTPNSE	DEG_SCF_FBW7_2	167:173	Mutation rewiring degron network	0.3056

Kaplan plot for ANKFN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKFN1

UniProt ID: Q8N957

Entrez ID: 162282

Protein name: Ankyrin repeat and fibronectin type-III domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKFN1 in