DegronMD

Uniprot ID: Q8N957

Source protein: Ankyrin repeat and fibronectin type-III domain-containing protein 1

Source gene: ANKFN1

Class: DEG_SCF_FBW7_2

Location: 167:173

E3 ligase: FBXW7

DEGRON score: 0.622

ASA_SCORE: 71.7714

COIL: 0.8669

CONS_SCORE: 0.5356

DSS_SCORE: 0.4259

HELIX: 0.0539

FCONS_SCORE: 1.0498

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D166N	TCGA-43-8118	LUSC	TCGA	LNTPNSE	DEG_SCF_FBW7_2	0.3056
p.D166N	DO45471	LUSC	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.3056
p.G174V	TCGA-50-5941	LUAD	TCGA	LNTPNSE	DEG_SCF_FBW7_2	0.3056
p.G174V	DO25528	LUAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.3056
p.P162Q	TCGA-BF-A1PU	SKCM	TCGA	LNTPNSE	DEG_SCF_FBW7_2	0.1944
p.P162Q	DO50278	SKCM	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.1944
p.P162R	TCGA-DK-A3IK	BLCA	TCGA	LNTPNSE	DEG_SCF_FBW7_2	0.1944
p.P162R	DO454	BLCA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.1944
p.L165P	DO50345	ESAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.2778
p.L165P	DO223116	ESCA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.2778
p.Q159R	DO234345	ESAD	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.1111
p.M183I	DO231016	LUSC	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.0556
p.E173K	DO222546	MELA	ICGC	LNTPNSE	DEG_SCF_FBW7_2	0.7022
p.S172N	SIDM00150	Colorectal Carcinoma	GDSC	LNTPNSE	DEG_SCF_FBW7_2	0.5958
p.S172N	ACH-000969	Colon/Colorectal Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	0.5958
p.S172N	KM12	large_intestine	COSMIC	LNTPNSE	DEG_SCF_FBW7_2	0.5958
p.T176A	SIDM01491	Colorectal Carcinoma	GDSC	LNTPNSE	DEG_SCF_FBW7_2	0.25
p.T176A	ACH-000342	Colon/Colorectal Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	0.25
p.D179G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LNTPNSE	DEG_SCF_FBW7_2	0.1667
p.D179G	ACH-000942	Leukemia	CCLE	LNTPNSE	DEG_SCF_FBW7_2	0.1667
p.P177S	ACH-001518	Endometrial/Uterine Cancer	CCLE	LNTPNSE	DEG_SCF_FBW7_2	0.2222
p.D166H	EPLC-272H	lung	COSMIC	LNTPNSE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N957	Ankyrin repeat and fibronectin type-III domain-containing protein 1	DEG_SCF_FBW7_2	167:173	LNTPNSE	FBXW7	0.622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons