DegronMD - Q8N9L1(ZIC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D300E	TCGA-37-4130	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.F295L	TCGA-55-1592	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1389
p.T309N	TCGA-64-5775	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7055
p.F295C	TCGA-66-2742	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1389
p.D300Y	TCGA-86-7701	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.R301H	TCGA-99-7458	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301H	SIDM00933	Breast Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301H	CAL-51	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301C	TCGA-A5-A0G2	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R294C	TCGA-AA-3680	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.R294C	TCGA-RD-A8N6	STAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.S305L	TCGA-AA-3984	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7667
p.S305L	TCGA-AA-A010	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7667
p.R294H	TCGA-AD-6889	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.R294H	SIDM00068	Colorectal Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.R294H	GEO	large intestine	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.V307M	TCGA-CV-A6JY	HNSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7208
p.H306Q	TCGA-D1-A17T	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7582
p.D300N	TCGA-D3-A2JF	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.D300N	TCGA-FW-A3R5	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.R301S	TCGA-DA-A1IB	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R293Q	TCGA-VQ-A91K	STAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0833
p.D311E	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R293W	SIDM00217	Colorectal Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0833
p.R293W	SNU-1040	large intestine	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0833
p.T315A	SIDM00170	Head and Neck Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1944
p.R319W	SIDM01611	Endometrial Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0833
p.P303L	EN	endometrium	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7582
p.R320S	NCI-H847	lung	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0556
p.R320H	OCUB-M	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0556
p.T314S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2222

Kaplan plot for ZIC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZIC4

UniProt ID: Q8N9L1

Entrez ID: 84107

Protein name: Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZIC4 in