DegronMD - Q8N9L1(ZIC4)

FUNCTION: Binds to DNA. {ECO:0000250}.

GO - Biological processes (BP): central nervous system development [GO:0007417]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA binding [GO:1990837]

GO - Cellular component (CC): nucleus [GO:0005634]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
TPSALVSPS	DEG_SIAH_1	SIAH1,SIAH2,SIAH3	Zinc finger protein ZIC 4	302:310	More..

Showing 1 to 1 of 1 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S305L	TCGA-AA-3984	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7667
p.S305L	TCGA-AA-A010	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7667
p.H306Q	TCGA-D1-A17T	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7582
p.P303L	EN	endometrium	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7582
p.V307M	TCGA-CV-A6JY	HNSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7208
p.T309N	TCGA-64-5775	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7055
p.R301H	TCGA-99-7458	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301H	SIDM00933	Breast Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301H	CAL-51	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301C	TCGA-A5-A0G2	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.R301S	TCGA-DA-A1IB	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.D311E	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.3056
p.D300E	TCGA-37-4130	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.D300Y	TCGA-86-7701	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.D300N	TCGA-D3-A2JF	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.D300N	TCGA-FW-A3R5	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2778
p.T314S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.2222
p.T315A	SIDM00170	Head and Neck Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1944
p.F295L	TCGA-55-1592	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1389
p.F295C	TCGA-66-2742	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1389

Showing 1 to 20 of 31 entries

Previous1 2Next

No resistance data available for this Degron.

Kaplan plot for ZIC4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZIC4

UniProt ID: Q8N9L1

Entrez ID: 84107

Protein name: Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for ZIC4 in