DegronMD

Uniprot ID: Q8N9L1

Source protein: Zinc finger protein ZIC 4

Source gene: ZIC4

Class: DEG_SIAH_1

Location: 302:310

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9873

ASA_SCORE: 70.5

COIL: 0.8686

CONS_SCORE: 0.5235

DSS_SCORE: 0.5493

HELIX: 0.0674

FCONS_SCORE: 0.9057

RIG_SCORE: 0.6237

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D300E	TCGA-37-4130	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.F295L	TCGA-55-1592	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1389
p.T309N	TCGA-64-5775	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7055
p.F295C	TCGA-66-2742	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.1389
p.D300Y	TCGA-86-7701	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.R301H	TCGA-99-7458	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301H	SIDM00933	Breast Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301H	CAL-51	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301C	TCGA-A5-A0G2	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.R294C	TCGA-AA-3680	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294C	TCGA-RD-A8N6	STAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.S305L	TCGA-AA-3984	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7667
p.S305L	TCGA-AA-A010	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7667
p.R294H	TCGA-AD-6889	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294H	SIDM00068	Colorectal Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294H	GEO	large_intestine	COSMIC	TPSALVSPS	DEG_SIAH_1	0.1111
p.V307M	TCGA-CV-A6JY	HNSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.7208
p.H306Q	TCGA-D1-A17T	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	0.7582
p.D300N	TCGA-D3-A2JF	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.D300N	TCGA-FW-A3R5	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.R301S	TCGA-DA-A1IB	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.R293Q	TCGA-VQ-A91K	STAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.0833
p.D311E	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TPSALVSPS	DEG_SIAH_1	0.3056
p.R293W	SIDM00217	Colorectal Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.0833
p.R293W	SNU-1040	large_intestine	COSMIC	TPSALVSPS	DEG_SIAH_1	0.0833
p.T315A	SIDM00170	Head and Neck Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.1944
p.R319W	SIDM01611	Endometrial Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.0833
p.P303L	EN	endometrium	COSMIC	TPSALVSPS	DEG_SIAH_1	0.7582
p.R320S	NCI-H847	lung	COSMIC	TPSALVSPS	DEG_SIAH_1	0.0556
p.R320H	OCUB-M	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	0.0556
p.T314S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TPSALVSPS	DEG_SIAH_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TPSALVSPS

Degron related mutations and impact score

Drug responses associated with ZIC4 mutations

All proteins holding degron of TPSALVSPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9L1	Zinc finger protein ZIC 4	DEG_SIAH_1	302:310	TPSALVSPS	SIAH1,SIAH2,SIAH3	0.9873	More...