DegronMD

Uniprot ID: Q8N9L1

Source protein: Zinc finger protein ZIC 4

Source gene: ZIC4

Class: DEG_SIAH_1

Location: 302:310

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9873

ASA_SCORE: 70.5

COIL: 0.8686

CONS_SCORE: 0.5235

DSS_SCORE: 0.5493

HELIX: 0.0674

FCONS_SCORE: 0.9057

RIG_SCORE: 0.6237

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S305L	TCGA-AA-3984	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7667
p.S305L	TCGA-AA-A010	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7667
p.H306Q	TCGA-D1-A17T	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	0.7582
p.P303L	EN	endometrium	COSMIC	TPSALVSPS	DEG_SIAH_1	0.7582
p.V307M	TCGA-CV-A6JY	HNSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.7208
p.T309N	TCGA-64-5775	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.7055
p.R301H	TCGA-99-7458	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301H	SIDM00933	Breast Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301H	CAL-51	breast	COSMIC	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301C	TCGA-A5-A0G2	UCEC	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.R301S	TCGA-DA-A1IB	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.3056
p.D311E	SIDM00502	B-Lymphoblastic Leukemia	GDSC	TPSALVSPS	DEG_SIAH_1	0.3056
p.D300E	TCGA-37-4130	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.D300Y	TCGA-86-7701	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.D300N	TCGA-D3-A2JF	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.D300N	TCGA-FW-A3R5	SKCM	TCGA	TPSALVSPS	DEG_SIAH_1	0.2778
p.T314S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TPSALVSPS	DEG_SIAH_1	0.2222
p.T315A	SIDM00170	Head and Neck Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.1944
p.F295L	TCGA-55-1592	LUAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1389
p.F295C	TCGA-66-2742	LUSC	TCGA	TPSALVSPS	DEG_SIAH_1	0.1389
p.R294C	TCGA-AA-3680	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294C	TCGA-RD-A8N6	STAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294H	TCGA-AD-6889	COAD	TCGA	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294H	SIDM00068	Colorectal Carcinoma	GDSC	TPSALVSPS	DEG_SIAH_1	0.1111
p.R294H	GEO	large_intestine	COSMIC	TPSALVSPS	DEG_SIAH_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9L1	Zinc finger protein ZIC 4	DEG_SIAH_1	302:310	TPSALVSPS	SIAH1,SIAH2,SIAH3	0.9873	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons