DegronMD - Q8N9V3(WDSUB1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V456I	TCGA-B5-A3FC	UCEC	TCGA	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.5965
p.V456I	DO41871	UCEC	ICGC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.5965
p.S454L	TCGA-CR-6481	HNSC	TCGA	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2778
p.S454L	DO14990	HNSC	ICGC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2778
p.M465L	TCGA-GN-A4U3	SKCM	TCGA	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.M465L	DO219484	SKCM	ICGC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.25
p.L450I	DO228948	LICA	ICGC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.1667
p.A466D	DO229019	LICA	ICGC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation rewiring degron network	0.2222
p.R461K	SIDM00655	Other Solid Cancers	GDSC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.6126
p.R461K	NCCIT	testis	COSMIC	VLTPNRT	DEG_SCF_FBW7_1	456:462	Mutation altering degron motif	0.6126

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons