DegronMD

Uniprot ID: Q8N9V3

Source protein: WD repeat, SAM and U-box domain-containing protein 1

Source gene: WDSUB1

Class: DEG_SCF_FBW7_1

Location: 456:462

E3 ligase: FBXW7

DEGRON score: 0.788

ASA_SCORE: 62.5857

COIL: 0.4767

CONS_SCORE: 0.6382

DSS_SCORE: 0.2955

HELIX: 0.3316

FCONS_SCORE: 1.0566

RIG_SCORE: 0.8038

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V456I	TCGA-B5-A3FC	UCEC	TCGA	VLTPNRT	DEG_SCF_FBW7_1	0.5965
p.V456I	DO41871	UCEC	ICGC	VLTPNRT	DEG_SCF_FBW7_1	0.5965
p.S454L	TCGA-CR-6481	HNSC	TCGA	VLTPNRT	DEG_SCF_FBW7_1	0.2778
p.S454L	DO14990	HNSC	ICGC	VLTPNRT	DEG_SCF_FBW7_1	0.2778
p.M465L	TCGA-GN-A4U3	SKCM	TCGA	VLTPNRT	DEG_SCF_FBW7_1	0.25
p.M465L	DO219484	SKCM	ICGC	VLTPNRT	DEG_SCF_FBW7_1	0.25
p.L450I	DO228948	LICA	ICGC	VLTPNRT	DEG_SCF_FBW7_1	0.1667
p.A466D	DO229019	LICA	ICGC	VLTPNRT	DEG_SCF_FBW7_1	0.2222
p.R461K	SIDM00655	Other Solid Cancers	GDSC	VLTPNRT	DEG_SCF_FBW7_1	0.6126
p.R461K	NCCIT	testis	COSMIC	VLTPNRT	DEG_SCF_FBW7_1	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9V3	WD repeat, SAM and U-box domain-containing protein 1	DEG_SCF_FBW7_1	456:462	VLTPNRT	FBXW7	0.788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons