DegronMD - Q8N9W6(BOLL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P245Q	TCGA-43-3394	LUSC	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.3056
p.S226Y	TCGA-B5-A3FA	UCEC	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.0833
p.Q231R	TCGA-CG-5733	STAD	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2222
p.E250K	TCGA-DX-A6BA	SARC	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1667
p.E227K	TCGA-EA-A3HU	CESC	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1111
p.Y230N	TCGA-H4-A2HO	BLCA	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1944
p.A236V	TCGA-LT-A8JT	BLCA	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.6936
p.M249I	TCGA-YD-A9TA	SKCM	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1944
p.S252L	TCGA-Z2-A8RT	SKCM	TCGA	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1111
p.E243D	DO7938	COAD	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.5647
p.V250D	DO233196	GACA	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1667
p.E243A	DO49031	HNSC	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.7701
p.P231T	DO229019	LICA	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2222
p.S246F	DO231906	LINC	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2778
p.P233Q	DO26596	LUSC	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2778
p.E238K	DO219995	SARC	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.7022
p.S240L	DO51301	SKCM	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.6556
p.M237I	DO219503	SKCM	ICGC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.6507
p.G240A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.754
p.G240A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.754
p.Q237K	SIDM00120	Prostate Carcinoma	GDSC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.6944
p.Q237K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.6944
p.L246P	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2778
p.L246P	H9	haematopoietic and lymphoid tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.2778
p.F230S	ACH-000197	Leukemia	CCLE	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1944
p.F230S	TALL-1	haematopoietic and lymphoid tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1944
p.G250A	ACH-000510	Lung Cancer	CCLE	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1667
p.G250A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1667
p.Q247K	ACH-000979	Prostate Cancer	CCLE	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.25
p.Q247K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.25
p.A225S	ACH-002340	Neuroblastoma	CCLE	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.0556
p.A225S	NBsusSR	autonomic ganglia	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.0556
p.L234P	H9	haematopoietic and lymphoid tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.3056
p.Q225K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.0556
p.P244T	HCC1569	breast	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation altering degron motif	0.7031
p.G228A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	235:244	Mutation rewiring degron network	0.1389

Kaplan plot for BOLL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BOLL

UniProt ID: Q8N9W6

Entrez ID: 66037

Protein name: Protein boule-like

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BOLL in