DegronMD

Uniprot ID: Q8N9W6

Source protein: Protein boule-like

Source gene: BOLL

Class: DEG_COP1_1

Location: 235:244

E3 ligase: COP1

DEGRON score: 0.7823

ASA_SCORE: 78.2

COIL: 0.9063

CONS_SCORE: 0.3369

DSS_SCORE: 0.488

HELIX: 0.0549

FCONS_SCORE: 1.0468

RIG_SCORE: 0.7017

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P245Q	TCGA-43-3394	LUSC	TCGA	SLMETSVPEP	DEG_COP1_1	0.3056
p.S226Y	TCGA-B5-A3FA	UCEC	TCGA	SLMETSVPEP	DEG_COP1_1	0.0833
p.Q231R	TCGA-CG-5733	STAD	TCGA	SLMETSVPEP	DEG_COP1_1	0.2222
p.E250K	TCGA-DX-A6BA	SARC	TCGA	SLMETSVPEP	DEG_COP1_1	0.1667
p.E227K	TCGA-EA-A3HU	CESC	TCGA	SLMETSVPEP	DEG_COP1_1	0.1111
p.Y230N	TCGA-H4-A2HO	BLCA	TCGA	SLMETSVPEP	DEG_COP1_1	0.1944
p.A236V	TCGA-LT-A8JT	BLCA	TCGA	SLMETSVPEP	DEG_COP1_1	0.6936
p.M249I	TCGA-YD-A9TA	SKCM	TCGA	SLMETSVPEP	DEG_COP1_1	0.1944
p.S252L	TCGA-Z2-A8RT	SKCM	TCGA	SLMETSVPEP	DEG_COP1_1	0.1111
p.E243D	DO7938	COAD	ICGC	SLMETSVPEP	DEG_COP1_1	0.5647
p.V250D	DO233196	GACA	ICGC	SLMETSVPEP	DEG_COP1_1	0.1667
p.E243A	DO49031	HNSC	ICGC	SLMETSVPEP	DEG_COP1_1	0.7701
p.P231T	DO229019	LICA	ICGC	SLMETSVPEP	DEG_COP1_1	0.2222
p.S246F	DO231906	LINC	ICGC	SLMETSVPEP	DEG_COP1_1	0.2778
p.P233Q	DO26596	LUSC	ICGC	SLMETSVPEP	DEG_COP1_1	0.2778
p.E238K	DO219995	SARC	ICGC	SLMETSVPEP	DEG_COP1_1	0.7022
p.S240L	DO51301	SKCM	ICGC	SLMETSVPEP	DEG_COP1_1	0.6556
p.M237I	DO219503	SKCM	ICGC	SLMETSVPEP	DEG_COP1_1	0.6507
p.G240A	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	SLMETSVPEP	DEG_COP1_1	0.754
p.G240A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	0.754
p.Q237K	SIDM00120	Prostate Carcinoma	GDSC	SLMETSVPEP	DEG_COP1_1	0.6944
p.Q237K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	0.6944
p.L246P	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	SLMETSVPEP	DEG_COP1_1	0.2778
p.L246P	H9	haematopoietic_and_lymphoid_tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	0.2778
p.F230S	ACH-000197	Leukemia	CCLE	SLMETSVPEP	DEG_COP1_1	0.1944
p.F230S	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	0.1944
p.G250A	ACH-000510	Lung Cancer	CCLE	SLMETSVPEP	DEG_COP1_1	0.1667
p.G250A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	0.1667
p.Q247K	ACH-000979	Prostate Cancer	CCLE	SLMETSVPEP	DEG_COP1_1	0.25
p.Q247K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	0.25
p.A225S	ACH-002340	Neuroblastoma	CCLE	SLMETSVPEP	DEG_COP1_1	0.0556
p.A225S	NBsusSR	autonomic_ganglia	COSMIC	SLMETSVPEP	DEG_COP1_1	0.0556
p.L234P	H9	haematopoietic_and_lymphoid_tissue	COSMIC	SLMETSVPEP	DEG_COP1_1	0.3056
p.Q225K	DU-145	prostate	COSMIC	SLMETSVPEP	DEG_COP1_1	0.0556
p.P244T	HCC1569	breast	COSMIC	SLMETSVPEP	DEG_COP1_1	0.7031
p.G228A	NCI-H1299	lung	COSMIC	SLMETSVPEP	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SLMETSVPEP

Degron related mutations and impact score

Drug responses associated with BOLL mutations

All proteins holding degron of SLMETSVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N9W6	Protein boule-like	DEG_COP1_1	235:244	SLMETSVPEP	COP1	0.7823	More...