TERB1
UniProt ID: Q8NA31
Entrez ID: 283847
Protein name: Telomere repeats-binding bouquet formation protein 1 (Coiled-coil domain-containing protein 79)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA ...
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. {ECO:0000250|UniProtKB:Q8C0V1}.
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GO - Biological processes (BP):
homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]...
homologous chromosome pairing at meiosis [GO:0007129]; meiotic attachment of telomere to nuclear envelope [GO:0070197]; meiotic telomere clustering [GO:0045141]
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; shelterin complex [GO:0070187]...
chromosome, telomeric region [GO:0000781]; nuclear inner membrane [GO:0005637]; shelterin complex [GO:0070187]
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TERB1
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*NOTE: the Kaplan plots were collected from OncoLnc