DegronMD

Uniprot ID: Q8NA31

Source protein: Telomere repeats-binding bouquet formation protein 1

Source gene: TERB1

Class: DEG_SCF_FBW7_1

Location: 491:497

E3 ligase: FBXW7

DEGRON score: 0.8906

ASA_SCORE: 103.8714

COIL: 0.7674

CONS_SCORE: 0.3029

DSS_SCORE: 0.4793

HELIX: 0.1861

FCONS_SCORE: 0.9245

RIG_SCORE: 0.7093

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P494L	SIDM00014	Colorectal Carcinoma	GDSC	MKTPLKS	DEG_SCF_FBW7_1	0.7582
p.P494L	LIM1215	large_intestine	COSMIC	MKTPLKS	DEG_SCF_FBW7_1	0.7582
p.A498T	CW-2	large_intestine	COSMIC	MKTPLKS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA31	Telomere repeats-binding bouquet formation protein 1	DEG_SCF_FBW7_1	491:497	MKTPLKS	FBXW7	0.8906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons