DegronMD - Q8NA56(TTC29)

TTC29

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R11C	TCGA-55-6975	LUAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.8301
p.R11S	TCGA-56-7222	LUSC	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7427
p.A18P	TCGA-99-8025	LUAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.6392
p.P12L	TCGA-FR-A69P	SKCM	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.6471
p.R19T	TCGA-HF-7134	STAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.3056
p.S25Y	DO50092	COAD	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1389
p.P3L	DO50346	ESAD	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation substituting flanking lysine	0.25
p.T8I	DO228974	LICA	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation substituting flanking lysine	0.3889
p.G13E	DO26710	LUSC	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.7199
p.E26K	DO47362	SKCM	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1111
p.E26K	DO38123	SKCM	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation rewiring degron network	0.1111
p.R11H	HT-115	large intestine	COSMIC	TRPKLTALA	DEG_APCC_DBOX_1	10:18	Mutation altering degron motif	0.8244

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*NOTE: the Kaplan plots were collected from OncoLnc