DegronMD

Uniprot ID: Q8NA56

Source protein: Tetratricopeptide repeat protein 29

Source gene: TTC29

Class: DEG_APCC_DBOX_1

Location: 10:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9349

ASA_SCORE: 85.6889

COIL: 0.6057

CONS_SCORE: 0.5832

DSS_SCORE: 0.5585

HELIX: 0.3841

FCONS_SCORE: 1.0468

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11C	TCGA-55-6975	LUAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	0.8301
p.R11S	TCGA-56-7222	LUSC	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	0.7427
p.A18P	TCGA-99-8025	LUAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	0.6392
p.P12L	TCGA-FR-A69P	SKCM	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	0.6471
p.R19T	TCGA-HF-7134	STAD	TCGA	TRPKLTALA	DEG_APCC_DBOX_1	0.3056
p.S25Y	DO50092	COAD	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.1389
p.P3L	DO50346	ESAD	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.25
p.T8I	DO228974	LICA	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.3889
p.G13E	DO26710	LUSC	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.7199
p.E26K	DO47362	SKCM	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.1111
p.E26K	DO38123	SKCM	ICGC	TRPKLTALA	DEG_APCC_DBOX_1	0.1111
p.R11H	HT-115	large_intestine	COSMIC	TRPKLTALA	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA56	Tetratricopeptide repeat protein 29	DEG_APCC_DBOX_1	10:18	TRPKLTALA	APC,CDC20,FZR1	0.9349	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons