DegronMD - Q8NA57(C12orf50)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R290I	TCGA-E6-A1LX	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	TCGA-F5-6814	READ	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	SIDM00193	Colorectal Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	ACH-000991	Colon/Colorectal Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.Y295H	DO229505	LAML	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.7229
p.E291K	DO220891	MELA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.7022
p.A290V	DO47775	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.6936
p.A293V	DO42280	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.6936
p.P297Q	TCGA-D3-A3C6	SKCM	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.3056
p.N285I	DO218269	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.3056
p.K288N	TCGA-EY-A1G8	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.Q298H	TCGA-FI-A2D5	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.R288Q	DO225239	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.R288Q	DO48246	ESCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.Q298K	SIDM00845	Burkitt's Lymphoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.Q298K	ACH-000786	Lymphoma	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.N287T	DO219773	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.25
p.K286E	DO51935	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222
p.R300G	DO26508	LUSC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222
p.K286I	DO47847	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 44 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

C12orf50

UniProt ID: Q8NA57

Entrez ID: 160419

Protein name: Uncharacterized protein C12orf50

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C12orf50 in