DegronMD - Q8NA57(C12orf50)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P301L	TCGA-77-8133	LUSC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1944
p.K280N	TCGA-AP-A0LM	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.F284V	TCGA-D1-A16X	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1667
p.P297Q	TCGA-D3-A3C6	SKCM	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.3056
p.R290I	TCGA-E6-A1LX	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	TCGA-F5-6814	READ	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	SIDM00193	Colorectal Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.R290I	ACH-000991	Colon/Colorectal Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.8102
p.M305I	TCGA-E7-A4IJ	BLCA	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.0833
p.K288N	TCGA-EY-A1G8	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.K281R	TCGA-EY-A215	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1944
p.Q298H	TCGA-FI-A2D5	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.H283Y	TCGA-FW-A3R5	SKCM	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1389
p.S303Y	TCGA-IB-7651	PAAD	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1389
p.K281Q	TCGA-LN-A49W	ESCA	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1944
p.K286E	DO51935	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222
p.H282D	DO44029	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1111
p.H282Y	DO219043	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1111
p.H282Y	DO37406	SKCM	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1111
p.R288Q	DO225239	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.R288Q	DO48246	ESCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.N285I	DO218269	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.3056
p.A302G	DO8055	COAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1667
p.Y295H	DO229505	LAML	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.7229
p.A302D	DO229026	LICA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1667
p.R300G	DO26508	LUSC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222
p.E291K	DO220891	MELA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.7022
p.D301N	DO220239	SARC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1944
p.R304K	DO37432	SKCM	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1111
p.K286I	DO47847	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2222
p.A290V	DO47775	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.6936
p.N287T	DO219773	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.25
p.A293V	DO42280	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation altering degron motif	0.6936
p.Q298K	SIDM00845	Burkitt's Lymphoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.Q298K	ACH-000786	Lymphoma	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.2778
p.K280R	SIDM00845	Burkitt's Lymphoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.K280R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.K280R	SIDM01519	Head and Neck Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.K280R	ACH-000786	Lymphoma	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.K280R	ACH-000992	Head and Neck Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1667
p.F284I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1667
p.F284I	ACH-000860	Lung Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation rewiring degron network	0.1667
p.K281M	SIDM01611	Endometrial Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1944
p.K281M	ACH-000996	Endometrial/Uterine Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	290:296	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C12orf50

UniProt ID: Q8NA57

Entrez ID: 160419

Protein name: Uncharacterized protein C12orf50

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C12orf50 in