DegronMD

Uniprot ID: Q8NA57

Source protein: Uncharacterized protein C12orf50

Source gene: C12orf50

Class: LIG_APCC_ABBAyCdc20_2

Location: 290:296

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6885

ASA_SCORE: 118.9857

COIL: 0.8024

CONS_SCORE: 0.9498

DSS_SCORE: 0.5185

HELIX: 0.0213

FCONS_SCORE: 1.0889

RIG_SCORE: 0.7949

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P301L	TCGA-77-8133	LUSC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K280N	TCGA-AP-A0LM	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F284V	TCGA-D1-A16X	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P297Q	TCGA-D3-A3C6	SKCM	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R290I	TCGA-E6-A1LX	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R290I	TCGA-F5-6814	READ	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R290I	SIDM00193	Colorectal Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R290I	ACH-000991	Colon/Colorectal Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.M305I	TCGA-E7-A4IJ	BLCA	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.0833
p.K288N	TCGA-EY-A1G8	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K281R	TCGA-EY-A215	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q298H	TCGA-FI-A2D5	UCEC	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H283Y	TCGA-FW-A3R5	SKCM	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S303Y	TCGA-IB-7651	PAAD	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.K281Q	TCGA-LN-A49W	ESCA	TCGA	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K286E	DO51935	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H282D	DO44029	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H282Y	DO219043	BLCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H282Y	DO37406	SKCM	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R288Q	DO225239	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R288Q	DO48246	ESCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.N285I	DO218269	BRCA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A302G	DO8055	COAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Y295H	DO229505	LAML	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.7229
p.A302D	DO229026	LICA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R300G	DO26508	LUSC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E291K	DO220891	MELA	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.7022
p.D301N	DO220239	SARC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R304K	DO37432	SKCM	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.K286I	DO47847	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A290V	DO47775	STAD	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.6936
p.N287T	DO219773	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.25
p.A293V	DO42280	UCEC	ICGC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.6936
p.Q298K	SIDM00845	Burkitt's Lymphoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q298K	ACH-000786	Lymphoma	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K280R	SIDM00845	Burkitt's Lymphoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K280R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K280R	SIDM01519	Head and Neck Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K280R	ACH-000786	Lymphoma	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K280R	ACH-000992	Head and Neck Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F284I	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.F284I	ACH-000860	Lung Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K281M	SIDM01611	Endometrial Carcinoma	GDSC	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K281M	ACH-000996	Endometrial/Uterine Cancer	CCLE	RKWIYDE	LIG_APCC_ABBAyCdc20_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKWIYDE

Degron related mutations and impact score

Drug responses associated with C12orf50 mutations

All proteins holding degron of RKWIYDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NA57	Uncharacterized protein C12orf50	LIG_APCC_ABBAyCdc20_2	290:296	RKWIYDE	APC,CDC20,FZR1	0.6885	More...