DegronMD - Q8NAC3(IL17RC)

FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:18684971, PubMed:17911633). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). {ECO:0000250|UniProtKB:Q8K4C2, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:32187518}.; FUNCTION: [Isoform 5]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 6]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 7]: Does not bind IL17A or IL17F. {ECO:0000269|PubMed:16785495}.; FUNCTION: [Isoform 8]: Receptor for both IL17A and IL17F. {ECO:0000269|PubMed:16785495}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S58G	TCGA-AA-3492	COAD	TCGA	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0833
p.S58G	DO8224	COAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0833
p.V62I	TCGA-AP-A059	UCEC	TCGA	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.V62I	DO41361	UCEC	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.V60G	DO4006	BRCA	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.V60M	DO10244	COAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.P57S	DO37567	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.P57S	DO50286	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.P57L	DO37567	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.0556
p.D79N	DO47769	STAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2222
p.L82I	DO223282	UCEC	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389

Kaplan plot for IL17RC in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL17RC

UniProt ID: Q8NAC3

Entrez ID: 84818

Protein name: Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL17RC in