DegronMD

Uniprot ID: Q8NAC3

Source protein: Interleukin-17 receptor C

Source gene: IL17RC

Class: DEG_APCC_DBOX_1

Location: 67:75

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.556

ASA_SCORE: 49.2444

COIL: 0.3947

CONS_SCORE: 0.2759

DSS_SCORE: 0.4208

HELIX: 0.5724

FCONS_SCORE: 1.0436

RIG_SCORE: 0.7423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S58G	TCGA-AA-3492	COAD	TCGA	ARTALSGLS	DEG_APCC_DBOX_1	0.0833
p.S58G	DO8224	COAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.0833
p.V62I	TCGA-AP-A059	UCEC	TCGA	ARTALSGLS	DEG_APCC_DBOX_1	0.1944
p.V62I	DO41361	UCEC	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.1944
p.V60G	DO4006	BRCA	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.1389
p.V60M	DO10244	COAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.1389
p.P57S	DO37567	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.0556
p.P57S	DO50286	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.0556
p.P57L	DO37567	SKCM	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.0556
p.D79N	DO47769	STAD	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.2222
p.L82I	DO223282	UCEC	ICGC	ARTALSGLS	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAC3	Interleukin-17 receptor C	DEG_APCC_DBOX_1	67:75	ARTALSGLS	APC,CDC20,FZR1	0.556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons