DegronMD - Q8NAF0(ZNF579)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S513T	TCGA-AD-6965	COAD	TCGA	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation blocking phosphorylation signal	0.75
p.S513T	DO9018	COAD	ICGC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation blocking phosphorylation signal	0.75
p.K508E	TCGA-BR-4361	STAD	TCGA	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation substituting flanking lysine	0.2778
p.K508E	DO38887	STAD	ICGC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation substituting flanking lysine	0.2778
p.A530S	TCGA-MA-AA42	CESC	TCGA	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.A530S	DO219724	CESC	ICGC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.A530T	DO222765	COCA	ICGC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.T516N	DO229022	LICA	ICGC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation altering degron motif	0.8166
p.P514L	SIDM00185	Melanoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation altering degron motif	0.6471
p.P514S	SIDM00185	Melanoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation altering degron motif	0.6752
p.A530V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.A530V	ACH-000718	Lung Cancer	CCLE	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.A530V	NCI-H2291	lung	COSMIC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.0556
p.P511L	SIDM00511	Small Cell Lung Carcinoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.25
p.P511L	ACH-000257	Lung Cancer	CCLE	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.25
p.P511L	COR-L279	lung	COSMIC	PGTPPQS	DEG_SCF_FBW7_1	514:520	Mutation rewiring degron network	0.25

Kaplan plot for ZNF579 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF579

UniProt ID: Q8NAF0

Entrez ID: 163033

Protein name: Zinc finger protein 579

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF579 in