DegronMD

Uniprot ID: Q8NAF0

Source protein: Zinc finger protein 579

Source gene: ZNF579

Class: DEG_SCF_FBW7_1

Location: 514:520

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 67.9

COIL: 0.8999

CONS_SCORE: 0.7069

DSS_SCORE: 0.8524

HELIX: 0.012

FCONS_SCORE: 1.3256

RIG_SCORE: 0.4712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S513T	TCGA-AD-6965	COAD	TCGA	PGTPPQS	DEG_SCF_FBW7_1	0.75
p.S513T	DO9018	COAD	ICGC	PGTPPQS	DEG_SCF_FBW7_1	0.75
p.K508E	TCGA-BR-4361	STAD	TCGA	PGTPPQS	DEG_SCF_FBW7_1	0.2778
p.K508E	DO38887	STAD	ICGC	PGTPPQS	DEG_SCF_FBW7_1	0.2778
p.A530S	TCGA-MA-AA42	CESC	TCGA	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.A530S	DO219724	CESC	ICGC	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.A530T	DO222765	COCA	ICGC	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.T516N	DO229022	LICA	ICGC	PGTPPQS	DEG_SCF_FBW7_1	0.8166
p.P514L	SIDM00185	Melanoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	0.6471
p.P514S	SIDM00185	Melanoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	0.6752
p.A530V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.A530V	ACH-000718	Lung Cancer	CCLE	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.A530V	NCI-H2291	lung	COSMIC	PGTPPQS	DEG_SCF_FBW7_1	0.0556
p.P511L	SIDM00511	Small Cell Lung Carcinoma	GDSC	PGTPPQS	DEG_SCF_FBW7_1	0.25
p.P511L	ACH-000257	Lung Cancer	CCLE	PGTPPQS	DEG_SCF_FBW7_1	0.25
p.P511L	COR-L279	lung	COSMIC	PGTPPQS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NAF0	Zinc finger protein 579	DEG_SCF_FBW7_1	514:520	PGTPPQS	FBXW7	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons